Application of biomaterials in experimentally induced alveolar bone osteoporosis
Rehabilitation of alveolar bone with tissue defect caused by advanced osteoporosis is a common problem in stomatology and maxillofacial surgery. One of therapeutic approaches is implantation of biomaterials. The aim of this study was to estimate biocompatibility, osteoconductive and reparative capab...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Medical Society - Dental Section, Belgrade
2003-01-01
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| Series: | Stomatološki glasnik Srbije |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0039-1743/2003/0039-17430301013A.pdf |
| _version_ | 1818524415017615360 |
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| author | Ajduković Zorica R. Mihailović Dragan S. Najman Stevo J. Savić Vojin P. Aleksov Ljiljana Stanković Saša Krunić Nebojša Ristić Kitka |
| author_facet | Ajduković Zorica R. Mihailović Dragan S. Najman Stevo J. Savić Vojin P. Aleksov Ljiljana Stanković Saša Krunić Nebojša Ristić Kitka |
| author_sort | Ajduković Zorica R. |
| collection | DOAJ |
| description | Rehabilitation of alveolar bone with tissue defect caused by advanced osteoporosis is a common problem in stomatology and maxillofacial surgery. One of therapeutic approaches is implantation of biomaterials. The aim of this study was to estimate biocompatibility, osteoconductive and reparative capabilities of biomaterials in wound healing of rats which are experimentally treated with corticosteroids during 12 weeks to produce osteoporosis. The syngenic Sprague Dolly female rats 6-8 weeks old were divided into the experimental and control groups. In the experimental group comprising 5 subgroups, the bone defects were made in the left mandible by 1.4 mm borer, in sterile conditions. In the first subgroup of rats healing wasspontaneous. In other four subgroups hydroxyapatite (HAp) composite, a mixture of HAp and autologous plasma, a mixture of HAp and fibrin glue, and glass jonomer bone cement were used, respectively. The best results were obtained with a mixture of HAp with plasma. Histologically, the new bone tissue was found in both spongious and compact mandibular parts. Our. results suggest that HAp can help in new bone tissue formation in animals treated with corticosteroids. |
| first_indexed | 2024-12-11T05:56:48Z |
| format | Article |
| id | doaj.art-f329e34a30a84b029532c5140f31cef9 |
| institution | Directory Open Access Journal |
| issn | 0039-1743 |
| language | English |
| last_indexed | 2024-12-11T05:56:48Z |
| publishDate | 2003-01-01 |
| publisher | Serbian Medical Society - Dental Section, Belgrade |
| record_format | Article |
| series | Stomatološki glasnik Srbije |
| spelling | doaj.art-f329e34a30a84b029532c5140f31cef92022-12-22T01:18:39ZengSerbian Medical Society - Dental Section, BelgradeStomatološki glasnik Srbije0039-17432003-01-01501131710.2298/SGS0301013AApplication of biomaterials in experimentally induced alveolar bone osteoporosisAjduković Zorica R.Mihailović Dragan S.Najman Stevo J.Savić Vojin P.Aleksov LjiljanaStanković SašaKrunić NebojšaRistić KitkaRehabilitation of alveolar bone with tissue defect caused by advanced osteoporosis is a common problem in stomatology and maxillofacial surgery. One of therapeutic approaches is implantation of biomaterials. The aim of this study was to estimate biocompatibility, osteoconductive and reparative capabilities of biomaterials in wound healing of rats which are experimentally treated with corticosteroids during 12 weeks to produce osteoporosis. The syngenic Sprague Dolly female rats 6-8 weeks old were divided into the experimental and control groups. In the experimental group comprising 5 subgroups, the bone defects were made in the left mandible by 1.4 mm borer, in sterile conditions. In the first subgroup of rats healing wasspontaneous. In other four subgroups hydroxyapatite (HAp) composite, a mixture of HAp and autologous plasma, a mixture of HAp and fibrin glue, and glass jonomer bone cement were used, respectively. The best results were obtained with a mixture of HAp with plasma. Histologically, the new bone tissue was found in both spongious and compact mandibular parts. Our. results suggest that HAp can help in new bone tissue formation in animals treated with corticosteroids.http://www.doiserbia.nb.rs/img/doi/0039-1743/2003/0039-17430301013A.pdfmandibleratcorticosteroidsalveolarbonehydroxiapatite. |
| spellingShingle | Ajduković Zorica R. Mihailović Dragan S. Najman Stevo J. Savić Vojin P. Aleksov Ljiljana Stanković Saša Krunić Nebojša Ristić Kitka Application of biomaterials in experimentally induced alveolar bone osteoporosis Stomatološki glasnik Srbije mandible rat corticosteroids alveolarbone hydroxiapatite. |
| title | Application of biomaterials in experimentally induced alveolar bone osteoporosis |
| title_full | Application of biomaterials in experimentally induced alveolar bone osteoporosis |
| title_fullStr | Application of biomaterials in experimentally induced alveolar bone osteoporosis |
| title_full_unstemmed | Application of biomaterials in experimentally induced alveolar bone osteoporosis |
| title_short | Application of biomaterials in experimentally induced alveolar bone osteoporosis |
| title_sort | application of biomaterials in experimentally induced alveolar bone osteoporosis |
| topic | mandible rat corticosteroids alveolarbone hydroxiapatite. |
| url | http://www.doiserbia.nb.rs/img/doi/0039-1743/2003/0039-17430301013A.pdf |
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