Panton-Valentine Leucocidin (PVL) as a Potential Indicator for Prevalence, Duration, and Severity of Staphylococcus aureus Osteomyelitis
Staphylococcus aureus is the most common cause of the difficult-to-treat osteomyelitis (OM). To better diagnose and manage S. aureus OM, especially for severe and long duration cases, indicators for risk prediction and severity evaluation are needed. Here, 139 clinical S. aureus isolates from orthop...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2017.02355/full |
| _version_ | 1818838344041234432 |
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| author | Bei Jiang Yinan Wang Zihan Feng Lei Xu Li Tan Shuang Zhao Yali Gong Cheng Zhang Xiaoqiang Luo Shu Li Xiancai Rao Yizhi Peng Zhao Xie Xiaomei Hu |
| author_facet | Bei Jiang Yinan Wang Zihan Feng Lei Xu Li Tan Shuang Zhao Yali Gong Cheng Zhang Xiaoqiang Luo Shu Li Xiancai Rao Yizhi Peng Zhao Xie Xiaomei Hu |
| author_sort | Bei Jiang |
| collection | DOAJ |
| description | Staphylococcus aureus is the most common cause of the difficult-to-treat osteomyelitis (OM). To better diagnose and manage S. aureus OM, especially for severe and long duration cases, indicators for risk prediction and severity evaluation are needed. Here, 139 clinical S. aureus isolates from orthopedic infections were divided into OM group (60 isolates from 60 OM patients) and non-OM group (79 isolates from 79 non-OM patients). Molecular types, antimicrobial susceptibility, and virulence factor profiles were evaluated and compared between the two groups to identify potential indicators associated with the prevalence of S. aureus OM. Clinical manifestations and laboratory data were analyzed to identify indicators affecting OM duration and severity. We found that some sequence types were specific to OM infection. The pvl, bbp, and ebps genes were associated with S. aureus OM prevalence. The pvl, bbp, and sei genes were associated with relatively longer OM duration. Panton-Valentine leucocidin (PVL)-positive S. aureus OM presented more serious inflammatory responses. Our results emphasize the significance of PVL in affecting the prevalence, duration, and severity of S. aureus OM. Diagnosing and monitoring PVL-related S. aureus OM may help direct better prognosis and treatment of these patients. |
| first_indexed | 2024-12-19T03:36:54Z |
| format | Article |
| id | doaj.art-f32a26cd028b4cb78c49f255993b26aa |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-19T03:36:54Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-f32a26cd028b4cb78c49f255993b26aa2022-12-21T20:37:22ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2017-11-01810.3389/fmicb.2017.02355299103Panton-Valentine Leucocidin (PVL) as a Potential Indicator for Prevalence, Duration, and Severity of Staphylococcus aureus OsteomyelitisBei Jiang0Yinan Wang1Zihan Feng2Lei Xu3Li Tan4Shuang Zhao5Yali Gong6Cheng Zhang7Xiaoqiang Luo8Shu Li9Xiancai Rao10Yizhi Peng11Zhao Xie12Xiaomei Hu13State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Microbiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, ChinaCadet Brigade, Third Military Medical University, Chongqing, ChinaCadet Brigade, Third Military Medical University, Chongqing, ChinaDepartment of Microbiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, ChinaCadet Brigade, Third Military Medical University, Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Microbiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, ChinaDepartment of Microbiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Orthopedics, Southwest Hospital, Third Military Medical University, Chongqing, ChinaDepartment of Microbiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, ChinaStaphylococcus aureus is the most common cause of the difficult-to-treat osteomyelitis (OM). To better diagnose and manage S. aureus OM, especially for severe and long duration cases, indicators for risk prediction and severity evaluation are needed. Here, 139 clinical S. aureus isolates from orthopedic infections were divided into OM group (60 isolates from 60 OM patients) and non-OM group (79 isolates from 79 non-OM patients). Molecular types, antimicrobial susceptibility, and virulence factor profiles were evaluated and compared between the two groups to identify potential indicators associated with the prevalence of S. aureus OM. Clinical manifestations and laboratory data were analyzed to identify indicators affecting OM duration and severity. We found that some sequence types were specific to OM infection. The pvl, bbp, and ebps genes were associated with S. aureus OM prevalence. The pvl, bbp, and sei genes were associated with relatively longer OM duration. Panton-Valentine leucocidin (PVL)-positive S. aureus OM presented more serious inflammatory responses. Our results emphasize the significance of PVL in affecting the prevalence, duration, and severity of S. aureus OM. Diagnosing and monitoring PVL-related S. aureus OM may help direct better prognosis and treatment of these patients.http://journal.frontiersin.org/article/10.3389/fmicb.2017.02355/fullStaphylococcus aureusPanton-Valentine leucocidin (PVL)osteomyelitismolecular epidemiologyvirulence factor |
| spellingShingle | Bei Jiang Yinan Wang Zihan Feng Lei Xu Li Tan Shuang Zhao Yali Gong Cheng Zhang Xiaoqiang Luo Shu Li Xiancai Rao Yizhi Peng Zhao Xie Xiaomei Hu Panton-Valentine Leucocidin (PVL) as a Potential Indicator for Prevalence, Duration, and Severity of Staphylococcus aureus Osteomyelitis Frontiers in Microbiology Staphylococcus aureus Panton-Valentine leucocidin (PVL) osteomyelitis molecular epidemiology virulence factor |
| title | Panton-Valentine Leucocidin (PVL) as a Potential Indicator for Prevalence, Duration, and Severity of Staphylococcus aureus Osteomyelitis |
| title_full | Panton-Valentine Leucocidin (PVL) as a Potential Indicator for Prevalence, Duration, and Severity of Staphylococcus aureus Osteomyelitis |
| title_fullStr | Panton-Valentine Leucocidin (PVL) as a Potential Indicator for Prevalence, Duration, and Severity of Staphylococcus aureus Osteomyelitis |
| title_full_unstemmed | Panton-Valentine Leucocidin (PVL) as a Potential Indicator for Prevalence, Duration, and Severity of Staphylococcus aureus Osteomyelitis |
| title_short | Panton-Valentine Leucocidin (PVL) as a Potential Indicator for Prevalence, Duration, and Severity of Staphylococcus aureus Osteomyelitis |
| title_sort | panton valentine leucocidin pvl as a potential indicator for prevalence duration and severity of staphylococcus aureus osteomyelitis |
| topic | Staphylococcus aureus Panton-Valentine leucocidin (PVL) osteomyelitis molecular epidemiology virulence factor |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2017.02355/full |
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