Epigenetic DNA Methylation of <i>EBI3</i> Modulates Human Interleukin-35 Formation via NFkB Signaling: A Promising Therapeutic Option in Ulcerative Colitis

Epigenetic DNA Methylation of <i>EBI3</i> Modulates Human Interleukin-35 Formation via NFkB Signaling: A Promising Therapeutic Option in Ulcerative Colitis

Ulcerative colitis (UC), a severe chronic disease with unclear etiology that is associated with increased risk for colorectal cancer, is accompanied by dysregulation of cytokines. <i>Epstein</i><i>–</i><i>Barr virus-induced gene 3 (EBI3)</i> encodes a subunit in t...

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Bibliographic Details
Main Authors: Alexandra Wetzel, Bettina Scholtka, Fabian Schumacher, Harshadrai Rawel, Birte Geisendörfer, Burkhard Kleuser
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
decitabine
DNMT inhibitor
EBI3
inhibitory cytokines
interleukin-35
TNFα
Online Access:https://www.mdpi.com/1422-0067/22/10/5329

Internet

https://www.mdpi.com/1422-0067/22/10/5329

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