Characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer in Korea
Abstract Background The aim of this study was to investigate the characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer (SCLC) using a nationwide registry in Korea. Methods The Korean Association for Lung Cancer developed a registry in cooperation with the Korean Ce...
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-022-01989-x |
| _version_ | 1811255077178966016 |
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| author | Hye Seon Kang Jung Uk Lim Chang Dong Yeo Chan Kwon Park Sang Haak Lee Seung Joon Kim Korean Association for Lung Cancer, Korea Central Cancer Registry |
| author_facet | Hye Seon Kang Jung Uk Lim Chang Dong Yeo Chan Kwon Park Sang Haak Lee Seung Joon Kim Korean Association for Lung Cancer, Korea Central Cancer Registry |
| author_sort | Hye Seon Kang |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to investigate the characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer (SCLC) using a nationwide registry in Korea. Methods The Korean Association for Lung Cancer developed a registry in cooperation with the Korean Central Cancer Registry (KCCR) and surveyed approximately 10% of recorded lung cancer cases. Results From 2014 to 2016, the KCCR registered 1,043 patients newly diagnosed with SCLC among a total of 8,110 lung cancer patients. In subgroup analysis, Kaplan meier survival analysis showed that the overall survival (OS) was significantly shorter in the nonsmoking subgroup than the ever-smoking subgroup of SCLC patients with extensive disease (6.99 vs. 9.68 months; P = 0.016). Among SCLC patients with limited disease, OS was also shorter in the nonsmoking subgroup, without statistical significance (19.4 vs. 23.5 months; P = 0.247). In a multivariate analysis using a Cox regression model, never smoking was not associated with shorter OS, but older age, extensive stage, poor performance status (Eastern Cooperative Oncology Group grade ≥ 2), male sex, no prophylactic cranial irradiation, and no active treatment (chemotherapy and/or radiotherapy) were associated with poor prognosis. Conclusion This evaluation of an unbiased nationwide survey dataset revealed that a significant proportion of Korean SCLC patients were never-smokers. No history of smoking appeared to be a significant prognostic factor according to the univariate analysis but was confirmed to be statistically insignificant through a multivariate analysis of the total population. Reasons for a poor prognosis may include the possibility that a high rate of the elderly population is composed of nonsmokers who did not receive active treatment. |
| first_indexed | 2024-04-12T17:18:19Z |
| format | Article |
| id | doaj.art-f32b26bda94941d287b942049f66604c |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-12T17:18:19Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-f32b26bda94941d287b942049f66604c2022-12-22T03:23:35ZengBMCBMC Pulmonary Medicine1471-24662022-05-012211910.1186/s12890-022-01989-xCharacteristics and clinical outcomes of patients with nonsmoking small cell lung cancer in KoreaHye Seon Kang0Jung Uk Lim1Chang Dong Yeo2Chan Kwon Park3Sang Haak Lee4Seung Joon Kim5Korean Association for Lung Cancer, Korea Central Cancer RegistryDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaAbstract Background The aim of this study was to investigate the characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer (SCLC) using a nationwide registry in Korea. Methods The Korean Association for Lung Cancer developed a registry in cooperation with the Korean Central Cancer Registry (KCCR) and surveyed approximately 10% of recorded lung cancer cases. Results From 2014 to 2016, the KCCR registered 1,043 patients newly diagnosed with SCLC among a total of 8,110 lung cancer patients. In subgroup analysis, Kaplan meier survival analysis showed that the overall survival (OS) was significantly shorter in the nonsmoking subgroup than the ever-smoking subgroup of SCLC patients with extensive disease (6.99 vs. 9.68 months; P = 0.016). Among SCLC patients with limited disease, OS was also shorter in the nonsmoking subgroup, without statistical significance (19.4 vs. 23.5 months; P = 0.247). In a multivariate analysis using a Cox regression model, never smoking was not associated with shorter OS, but older age, extensive stage, poor performance status (Eastern Cooperative Oncology Group grade ≥ 2), male sex, no prophylactic cranial irradiation, and no active treatment (chemotherapy and/or radiotherapy) were associated with poor prognosis. Conclusion This evaluation of an unbiased nationwide survey dataset revealed that a significant proportion of Korean SCLC patients were never-smokers. No history of smoking appeared to be a significant prognostic factor according to the univariate analysis but was confirmed to be statistically insignificant through a multivariate analysis of the total population. Reasons for a poor prognosis may include the possibility that a high rate of the elderly population is composed of nonsmokers who did not receive active treatment.https://doi.org/10.1186/s12890-022-01989-xSmall cell lung carcinomaNever-smokersKorea |
| spellingShingle | Hye Seon Kang Jung Uk Lim Chang Dong Yeo Chan Kwon Park Sang Haak Lee Seung Joon Kim Korean Association for Lung Cancer, Korea Central Cancer Registry Characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer in Korea BMC Pulmonary Medicine Small cell lung carcinoma Never-smokers Korea |
| title | Characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer in Korea |
| title_full | Characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer in Korea |
| title_fullStr | Characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer in Korea |
| title_full_unstemmed | Characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer in Korea |
| title_short | Characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer in Korea |
| title_sort | characteristics and clinical outcomes of patients with nonsmoking small cell lung cancer in korea |
| topic | Small cell lung carcinoma Never-smokers Korea |
| url | https://doi.org/10.1186/s12890-022-01989-x |
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