Prevalence of Suicidality in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Comparative Studies
Background: Suicidality is common in major depressive disorder (MDD), but there has been no systematic review published about all aspects of suicidality. This meta-analysis and systematic review compared the prevalence of the whole range of suicidality comprising suicidal ideation (SI), suicide plan...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.690130/full |
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| author | Hong Cai Hong Cai Hong Cai Xiao-Meng Xie Qinge Zhang Xiling Cui Jing-Xia Lin Kang Sim Gabor S. Ungvari Gabor S. Ungvari Ling Zhang Yu-Tao Xiang Yu-Tao Xiang Yu-Tao Xiang |
| author_facet | Hong Cai Hong Cai Hong Cai Xiao-Meng Xie Qinge Zhang Xiling Cui Jing-Xia Lin Kang Sim Gabor S. Ungvari Gabor S. Ungvari Ling Zhang Yu-Tao Xiang Yu-Tao Xiang Yu-Tao Xiang |
| author_sort | Hong Cai |
| collection | DOAJ |
| description | Background: Suicidality is common in major depressive disorder (MDD), but there has been no systematic review published about all aspects of suicidality. This meta-analysis and systematic review compared the prevalence of the whole range of suicidality comprising suicidal ideation (SI), suicide plan (SP), suicide attempt (SA), and completed suicide (CS), between patients with MDD and non-MDD controls.Methods: Major international (PubMed, PsycINFO, Web of Science, EMBASE) and Chinese (Chinese Nation Knowledge Infrastructure and WANFANG) databases were systematically and independently searched from their inception until January 12, 2021.Results: Fifteen studies covering 85,768 patients (12,668 in the MDD group and 73,100 in the non-MDD group) were included in the analyses. Compared to non-MDD controls, the odds ratios (ORs) for lifetime, past month, past year, and 2-week prevalence of SI in MDD were 2.88 [95% confidence interval (CI) = 0.30–27.22, p = 0.36], 49.88 (95% CI = 2–8.63, p < 0.001), 13.97 (95% CI = 12.67–15.41, p < 0.001), and 24.81 (95% CI = 15.70–39.22, p < 0.001), respectively. Compared to non-MDD controls, the OR for lifetime SP in MDD was 9.51 (95% CI = 7.62–11.88, p < 0.001). Compared to non-MDD controls, the ORs of lifetime and past-year prevalence of SA were 3.45 (95% CI = 1.58–7.52, p = 0.002), and 7.34 (95% CI = 2.14–25.16, p = 0.002), respectively, in MDD patients. No difference in the prevalence of CS between MDD and controls was found (OR = 0.69, 95% CI = 0.23–2.02, p = 0.50).Conclusions: MDD patients are at a higher risk of suicidality, compared to non-MDD controls. Routine screening for a range of suicidality should be included in the management of MDD, followed by timely treatment for suicidal patients.Systematic Review Registration: Identifier [INPLASY202120078]. |
| first_indexed | 2024-12-14T00:23:23Z |
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| issn | 1664-0640 |
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| last_indexed | 2024-12-14T00:23:23Z |
| publishDate | 2021-09-01 |
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| spelling | doaj.art-f32caaff41c843eab34633d007c0fe0e2022-12-21T23:25:08ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-09-011210.3389/fpsyt.2021.690130690130Prevalence of Suicidality in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Comparative StudiesHong Cai0Hong Cai1Hong Cai2Xiao-Meng Xie3Qinge Zhang4Xiling Cui5Jing-Xia Lin6Kang Sim7Gabor S. Ungvari8Gabor S. Ungvari9Ling Zhang10Yu-Tao Xiang11Yu-Tao Xiang12Yu-Tao Xiang13Unit of Psychiatry, Department of Public Health and Medicinal Administration, Faculty of Health Sciences, Institute of Translational Medicine, University of Macau, Macao, Macao, SAR ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macao, Macao, SAR ChinaInstitute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao, Macao, SAR ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Macao, Macao, SAR ChinaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Macao, Macao, SAR ChinaDepartment of Business Administration, Hong Kong Shue Yan University, Hong Kong, Hong Kong, SAR ChinaDepartment of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong, Hong Kong, SAR ChinaWest Region, Institute of Mental Health, Buangkok Green Medical Park, Singapore, SingaporeUniversity of Notre Dame Australia, Fremantle, WA, AustraliaDivision of Psychiatry, School of Medicine, University of Western Australia/Graylands Hospital, Perth, WA, AustraliaThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Macao, Macao, SAR ChinaUnit of Psychiatry, Department of Public Health and Medicinal Administration, Faculty of Health Sciences, Institute of Translational Medicine, University of Macau, Macao, Macao, SAR ChinaCentre for Cognitive and Brain Sciences, University of Macau, Macao, Macao, SAR ChinaInstitute of Advanced Studies in Humanities and Social Sciences, University of Macau, Macao, Macao, SAR ChinaBackground: Suicidality is common in major depressive disorder (MDD), but there has been no systematic review published about all aspects of suicidality. This meta-analysis and systematic review compared the prevalence of the whole range of suicidality comprising suicidal ideation (SI), suicide plan (SP), suicide attempt (SA), and completed suicide (CS), between patients with MDD and non-MDD controls.Methods: Major international (PubMed, PsycINFO, Web of Science, EMBASE) and Chinese (Chinese Nation Knowledge Infrastructure and WANFANG) databases were systematically and independently searched from their inception until January 12, 2021.Results: Fifteen studies covering 85,768 patients (12,668 in the MDD group and 73,100 in the non-MDD group) were included in the analyses. Compared to non-MDD controls, the odds ratios (ORs) for lifetime, past month, past year, and 2-week prevalence of SI in MDD were 2.88 [95% confidence interval (CI) = 0.30–27.22, p = 0.36], 49.88 (95% CI = 2–8.63, p < 0.001), 13.97 (95% CI = 12.67–15.41, p < 0.001), and 24.81 (95% CI = 15.70–39.22, p < 0.001), respectively. Compared to non-MDD controls, the OR for lifetime SP in MDD was 9.51 (95% CI = 7.62–11.88, p < 0.001). Compared to non-MDD controls, the ORs of lifetime and past-year prevalence of SA were 3.45 (95% CI = 1.58–7.52, p = 0.002), and 7.34 (95% CI = 2.14–25.16, p = 0.002), respectively, in MDD patients. No difference in the prevalence of CS between MDD and controls was found (OR = 0.69, 95% CI = 0.23–2.02, p = 0.50).Conclusions: MDD patients are at a higher risk of suicidality, compared to non-MDD controls. Routine screening for a range of suicidality should be included in the management of MDD, followed by timely treatment for suicidal patients.Systematic Review Registration: Identifier [INPLASY202120078].https://www.frontiersin.org/articles/10.3389/fpsyt.2021.690130/fullmajor depressive disordermeta-analysissuicide attemptcomparative studysuicidality |
| spellingShingle | Hong Cai Hong Cai Hong Cai Xiao-Meng Xie Qinge Zhang Xiling Cui Jing-Xia Lin Kang Sim Gabor S. Ungvari Gabor S. Ungvari Ling Zhang Yu-Tao Xiang Yu-Tao Xiang Yu-Tao Xiang Prevalence of Suicidality in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Comparative Studies Frontiers in Psychiatry major depressive disorder meta-analysis suicide attempt comparative study suicidality |
| title | Prevalence of Suicidality in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Comparative Studies |
| title_full | Prevalence of Suicidality in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Comparative Studies |
| title_fullStr | Prevalence of Suicidality in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Comparative Studies |
| title_full_unstemmed | Prevalence of Suicidality in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Comparative Studies |
| title_short | Prevalence of Suicidality in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Comparative Studies |
| title_sort | prevalence of suicidality in major depressive disorder a systematic review and meta analysis of comparative studies |
| topic | major depressive disorder meta-analysis suicide attempt comparative study suicidality |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.690130/full |
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