Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex
The visual brain has the remarkable capacity to complete our percept of the world even when the information extracted from the visual scene is incomplete. This ability to predict missing information based on information from spatially adjacent regions is an intriguing attribute of healthy vision. Ye...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921009630 |
| _version_ | 1819229475877945344 |
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| author | Joana Carvalho Remco J. Renken Frans W. Cornelissen |
| author_facet | Joana Carvalho Remco J. Renken Frans W. Cornelissen |
| author_sort | Joana Carvalho |
| collection | DOAJ |
| description | The visual brain has the remarkable capacity to complete our percept of the world even when the information extracted from the visual scene is incomplete. This ability to predict missing information based on information from spatially adjacent regions is an intriguing attribute of healthy vision. Yet, it gains particular significance when it masks the perceptual consequences of a retinal lesion, leaving patients unaware of their partial loss of vision and ultimately delaying diagnosis and treatment. At present, our understanding of the neural basis of this masking process is limited which hinders both quantitative modeling as well as translational application. To overcome this, we asked the participants to view visual stimuli with and without superimposed artificial scotoma (AS). We used fMRI to record the associated cortical activity and applied model-based analyzes to track changes in cortical population receptive fields and connectivity in response to the introduction of the AS. We found that throughout the visual field and cortical hierarchy, pRFs shifted their preferred position towards the AS border. Moreover, extrastriate areas biased their sampling of V1 towards sections outside the AS projection zone, thereby effectively masking the AS with signals from spared portions of the visual field. We speculate that the signals that drive these system-wide population modifications originate in extrastriate visual areas and, through feedback, also reconfigure the neural populations in the earlier visual areas. |
| first_indexed | 2024-12-23T11:13:46Z |
| format | Article |
| id | doaj.art-f32cfa3219b44782b7bd39d4ba3a0bf3 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-23T11:13:46Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-f32cfa3219b44782b7bd39d4ba3a0bf32022-12-21T17:49:16ZengElsevierNeuroImage1095-95722021-12-01245118690Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortexJoana Carvalho0Remco J. Renken1Frans W. Cornelissen2Laboratory of Experimental Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Laboratory of Preclinical MRI, Champalimaud Centre for the Unknown, Avenida de Brasília, Lisbon, Portugal 1400-038; Correspondence author at: Laboratory of Preclinical MRI, Champalimaud Centre for the Unknown, Avenida de Brasília, Lisbon 1400-038, Portugal.Cognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsLaboratory of Experimental Ophthalmology, University Medical Center Groningen, University of Groningen, Groningen, The NetherlandsThe visual brain has the remarkable capacity to complete our percept of the world even when the information extracted from the visual scene is incomplete. This ability to predict missing information based on information from spatially adjacent regions is an intriguing attribute of healthy vision. Yet, it gains particular significance when it masks the perceptual consequences of a retinal lesion, leaving patients unaware of their partial loss of vision and ultimately delaying diagnosis and treatment. At present, our understanding of the neural basis of this masking process is limited which hinders both quantitative modeling as well as translational application. To overcome this, we asked the participants to view visual stimuli with and without superimposed artificial scotoma (AS). We used fMRI to record the associated cortical activity and applied model-based analyzes to track changes in cortical population receptive fields and connectivity in response to the introduction of the AS. We found that throughout the visual field and cortical hierarchy, pRFs shifted their preferred position towards the AS border. Moreover, extrastriate areas biased their sampling of V1 towards sections outside the AS projection zone, thereby effectively masking the AS with signals from spared portions of the visual field. We speculate that the signals that drive these system-wide population modifications originate in extrastriate visual areas and, through feedback, also reconfigure the neural populations in the earlier visual areas.http://www.sciencedirect.com/science/article/pii/S1053811921009630PredictionMaskingPopulation receptive fieldConnective fieldReorganizationArtificial scotoma |
| spellingShingle | Joana Carvalho Remco J. Renken Frans W. Cornelissen Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex NeuroImage Prediction Masking Population receptive field Connective field Reorganization Artificial scotoma |
| title | Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex |
| title_full | Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex |
| title_fullStr | Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex |
| title_full_unstemmed | Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex |
| title_short | Predictive masking of an artificial scotoma is associated with a system-wide reconfiguration of neural populations in the human visual cortex |
| title_sort | predictive masking of an artificial scotoma is associated with a system wide reconfiguration of neural populations in the human visual cortex |
| topic | Prediction Masking Population receptive field Connective field Reorganization Artificial scotoma |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921009630 |
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