Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2
The COVID-19 outbreak seems to be the most dangerous challenge of the third millennium due to its highly contagious nature. Amongst natural molecules for COVID-19 treatment, the flavonoid molecule quercetin (QR) is currently considered one of the most promising. QR is an active agent against SARS an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/9/1049 |
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| author | Amin Gasmi Pavan Kumar Mujawdiya Roman Lysiuk Mariia Shanaida Massimiliano Peana Asma Gasmi Benahmed Nataliya Beley Nadiia Kovalska Geir Bjørklund |
| author_facet | Amin Gasmi Pavan Kumar Mujawdiya Roman Lysiuk Mariia Shanaida Massimiliano Peana Asma Gasmi Benahmed Nataliya Beley Nadiia Kovalska Geir Bjørklund |
| author_sort | Amin Gasmi |
| collection | DOAJ |
| description | The COVID-19 outbreak seems to be the most dangerous challenge of the third millennium due to its highly contagious nature. Amongst natural molecules for COVID-19 treatment, the flavonoid molecule quercetin (QR) is currently considered one of the most promising. QR is an active agent against SARS and MERS due to its antimicrobial, antiviral, anti-inflammatory, antioxidant, and some other beneficial effects. QR may hold therapeutic potential against SARS-CoV-2 due to its inhibitory effects on several stages of the viral life cycle. In fact, QR inhibits viral entry, absorption, and penetration in the SARS-CoV virus, which might be at least partly explained by the ability of QR and its derivatives to inhibit 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro). QR is a potent immunomodulatory molecule due to its direct modulatory effects on several immune cells, cytokines, and other immune molecules. QR-based nanopreparations possess enhanced bioavailability and solubility in water. In this review, we discuss the prospects for the application of QR as a preventive and treatment agent for COVID-19. Given the multifactorial beneficial action of QR, it can be considered a very valid drug as a preventative, mitigating, and therapeutic agent of COVID-19 infection, especially in synergism with zinc, vitamins C, D, and E, and other polyphenols. |
| first_indexed | 2024-03-09T22:52:48Z |
| format | Article |
| id | doaj.art-f3308796fa5b4b4493966753335b483a |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T22:52:48Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-f3308796fa5b4b4493966753335b483a2023-11-23T18:17:37ZengMDPI AGPharmaceuticals1424-82472022-08-01159104910.3390/ph15091049Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2Amin Gasmi0Pavan Kumar Mujawdiya1Roman Lysiuk2Mariia Shanaida3Massimiliano Peana4Asma Gasmi Benahmed5Nataliya Beley6Nadiia Kovalska7Geir Bjørklund8Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, 69100 Villeurbanne, FranceBirla Institute of Technology and Science-Pilani, Hyderabad 500078, IndiaDepartment of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University, 79010 Lviv, UkraineI. Horbachevsky Ternopil National Medical University, 46001 Ternopil, UkraineDepartment of Chemical, Physics, Mathematics and Natural Sciences, University of Sassari, 07100 Sassari, ItalyAcadémie Internationale de Médecine Dentaire Intégrative, 75000 Paris, FranceI. Horbachevsky Ternopil National Medical University, 46001 Ternopil, UkraineBogomolets National Medical University, 01601 Kyiv, UkraineCouncil for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610 Mo i Rana, NorwayThe COVID-19 outbreak seems to be the most dangerous challenge of the third millennium due to its highly contagious nature. Amongst natural molecules for COVID-19 treatment, the flavonoid molecule quercetin (QR) is currently considered one of the most promising. QR is an active agent against SARS and MERS due to its antimicrobial, antiviral, anti-inflammatory, antioxidant, and some other beneficial effects. QR may hold therapeutic potential against SARS-CoV-2 due to its inhibitory effects on several stages of the viral life cycle. In fact, QR inhibits viral entry, absorption, and penetration in the SARS-CoV virus, which might be at least partly explained by the ability of QR and its derivatives to inhibit 3-chymotrypsin-like protease (3CLpro) and papain-like protease (PLpro). QR is a potent immunomodulatory molecule due to its direct modulatory effects on several immune cells, cytokines, and other immune molecules. QR-based nanopreparations possess enhanced bioavailability and solubility in water. In this review, we discuss the prospects for the application of QR as a preventive and treatment agent for COVID-19. Given the multifactorial beneficial action of QR, it can be considered a very valid drug as a preventative, mitigating, and therapeutic agent of COVID-19 infection, especially in synergism with zinc, vitamins C, D, and E, and other polyphenols.https://www.mdpi.com/1424-8247/15/9/1049quercetincoronavirusCOVID-19infectionSARS-CoV-2nanopreparations |
| spellingShingle | Amin Gasmi Pavan Kumar Mujawdiya Roman Lysiuk Mariia Shanaida Massimiliano Peana Asma Gasmi Benahmed Nataliya Beley Nadiia Kovalska Geir Bjørklund Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2 Pharmaceuticals quercetin coronavirus COVID-19 infection SARS-CoV-2 nanopreparations |
| title | Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2 |
| title_full | Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2 |
| title_fullStr | Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2 |
| title_full_unstemmed | Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2 |
| title_short | Quercetin in the Prevention and Treatment of Coronavirus Infections: A Focus on SARS-CoV-2 |
| title_sort | quercetin in the prevention and treatment of coronavirus infections a focus on sars cov 2 |
| topic | quercetin coronavirus COVID-19 infection SARS-CoV-2 nanopreparations |
| url | https://www.mdpi.com/1424-8247/15/9/1049 |
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