Individual Oligogenic Background in p.D91A-<i>SOD1</i> Amyotrophic Lateral Sclerosis Patients

Individual Oligogenic Background in p.D91A-<i>SOD1</i> Amyotrophic Lateral Sclerosis Patients

The p.D91A is one of the most common ALS-causing <i>SOD1</i> mutations and is known to be either recessive or dominant. The homozygous phenotype is characterized by prolonged survival and slow progression of disease, whereas the affected heterozygous phenotypes can vary. To date, no gene...

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Bibliographic Details
Main Authors: Giulia Gentile, Benedetta Perrone, Giovanna Morello, Isabella Laura Simone, Sebastiano Andò, Sebastiano Cavallaro, Francesca Luisa Conforti
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Genes
Subjects:
p.D91A-<i>SOD1</i>
zygosity
NGS targeted-gene panel
individual oligogenic background
Online Access:https://www.mdpi.com/2073-4425/12/12/1843

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