HbA1c检测值低于7%的2型糖尿病患者血红细胞寿命缩短对HbA1c达标率的影响
Abstract Background Variations in the red blood cell (RBC) lifespan can affect glycosylated hemoglobin (HbA1c) test values, but there is still a lack of evidence regarding how and to what degree the RBC lifespan influences HbA1c in the type 2 diabetes mellitus (T2DM) population owing to the restrict...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13345 |
| _version_ | 1797945086323982336 |
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| author | Junmei Wang Li Zhang Yu bai Xinli Wang Weilin Wang Jing Li Saijun Zhou |
| author_facet | Junmei Wang Li Zhang Yu bai Xinli Wang Weilin Wang Jing Li Saijun Zhou |
| author_sort | Junmei Wang |
| collection | DOAJ |
| description | Abstract Background Variations in the red blood cell (RBC) lifespan can affect glycosylated hemoglobin (HbA1c) test values, but there is still a lack of evidence regarding how and to what degree the RBC lifespan influences HbA1c in the type 2 diabetes mellitus (T2DM) population owing to the restriction of traditional RBC lifespan–detection means. This study aimed to investigate the influence of RBC lifespan variation on HbA1c values in T2DM patients with a HbA1c detection value lower than 7%. Methods Patients with HbA1c <7% were divided into two groups: RBC lifespan <90 days and RBC lifespan ≥90 days. We collected blood glucose levels at seven time points for three consecutive months, assessed the HbA1c and glycosylated albumin levels, and calculated the hemoglobin glycation index (HGI) for each patient. Results There were no statistical differences in the HbA1c value between two groups, but the estimated glycosylated hemoglobin (eHbA1c) was significantly higher in patients with an RBC lifespan <90 days. The proportion of the eHbA1c ≥7% in the group with an RBC lifespan <90 days was significantly higher than the other group (33.87% vs. 12.50%, p < .01). Pearson analysis showed a significant negative correlation between RBC lifespan and the HGI in patients with T2DM (r = −0.348, p < .01). Conclusion A reduced RBC lifespan in T2DM patients caused a noticeable underestimate of the blood glucose levels as presented by HbA1c detection value. |
| first_indexed | 2024-04-10T20:48:37Z |
| format | Article |
| id | doaj.art-f33206a7efcd4a5a86684c60ca9b0a25 |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-04-10T20:48:37Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-f33206a7efcd4a5a86684c60ca9b0a252023-01-24T01:24:40ZengWileyJournal of Diabetes1753-03931753-04072023-01-0115171410.1111/1753-0407.13345HbA1c检测值低于7%的2型糖尿病患者血红细胞寿命缩短对HbA1c达标率的影响Junmei Wang0Li Zhang1Yu bai2Xinli Wang3Weilin Wang4Jing Li5Saijun Zhou6NHC Key Laboratory of Hormones and Development Chu Hsien‐I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University Tianjin ChinaNHC Key Laboratory of Hormones and Development Chu Hsien‐I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University Tianjin ChinaNHC Key Laboratory of Hormones and Development Chu Hsien‐I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University Tianjin ChinaNHC Key Laboratory of Hormones and Development Chu Hsien‐I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University Tianjin ChinaNHC Key Laboratory of Hormones and Development Chu Hsien‐I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University Tianjin ChinaNHC Key Laboratory of Hormones and Development Chu Hsien‐I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University Tianjin ChinaNHC Key Laboratory of Hormones and Development Chu Hsien‐I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University Tianjin ChinaAbstract Background Variations in the red blood cell (RBC) lifespan can affect glycosylated hemoglobin (HbA1c) test values, but there is still a lack of evidence regarding how and to what degree the RBC lifespan influences HbA1c in the type 2 diabetes mellitus (T2DM) population owing to the restriction of traditional RBC lifespan–detection means. This study aimed to investigate the influence of RBC lifespan variation on HbA1c values in T2DM patients with a HbA1c detection value lower than 7%. Methods Patients with HbA1c <7% were divided into two groups: RBC lifespan <90 days and RBC lifespan ≥90 days. We collected blood glucose levels at seven time points for three consecutive months, assessed the HbA1c and glycosylated albumin levels, and calculated the hemoglobin glycation index (HGI) for each patient. Results There were no statistical differences in the HbA1c value between two groups, but the estimated glycosylated hemoglobin (eHbA1c) was significantly higher in patients with an RBC lifespan <90 days. The proportion of the eHbA1c ≥7% in the group with an RBC lifespan <90 days was significantly higher than the other group (33.87% vs. 12.50%, p < .01). Pearson analysis showed a significant negative correlation between RBC lifespan and the HGI in patients with T2DM (r = −0.348, p < .01). Conclusion A reduced RBC lifespan in T2DM patients caused a noticeable underestimate of the blood glucose levels as presented by HbA1c detection value.https://doi.org/10.1111/1753-0407.13345糖化血红蛋白血糖均值红细胞寿命2型糖尿病 |
| spellingShingle | Junmei Wang Li Zhang Yu bai Xinli Wang Weilin Wang Jing Li Saijun Zhou HbA1c检测值低于7%的2型糖尿病患者血红细胞寿命缩短对HbA1c达标率的影响 Journal of Diabetes 糖化血红蛋白 血糖均值 红细胞寿命 2型糖尿病 |
| title | HbA1c检测值低于7%的2型糖尿病患者血红细胞寿命缩短对HbA1c达标率的影响 |
| title_full | HbA1c检测值低于7%的2型糖尿病患者血红细胞寿命缩短对HbA1c达标率的影响 |
| title_fullStr | HbA1c检测值低于7%的2型糖尿病患者血红细胞寿命缩短对HbA1c达标率的影响 |
| title_full_unstemmed | HbA1c检测值低于7%的2型糖尿病患者血红细胞寿命缩短对HbA1c达标率的影响 |
| title_short | HbA1c检测值低于7%的2型糖尿病患者血红细胞寿命缩短对HbA1c达标率的影响 |
| title_sort | hba1c检测值低于7 的2型糖尿病患者血红细胞寿命缩短对hba1c达标率的影响 |
| topic | 糖化血红蛋白 血糖均值 红细胞寿命 2型糖尿病 |
| url | https://doi.org/10.1111/1753-0407.13345 |
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