Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-β signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis

Connective tissue growth factor expression after angiotensin II exposure is dependent on transforming growth factor-β signaling via the canonical Smad-dependent pathway in hypertensive induced myocardial fibrosis

Introduction: Transforming growth factor-β (TGF-β) and connective tissue growth factor (CTGF) are often described as the initial pro-fibrotic mediators upregulated early in fibrosis models dependent on angiotensin II (Ang-II). In the present study, we explore the mechanistic link between TGF-β and C...

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Bibliographic Details
Main Authors:	Chloe Kok Sum Wong, Alec Falkenham, Tanya Myers, Jean-Francois Légaré
Format:	Article
Language:	English
Published:	SAGE Publications 2018-03-01
Series:	Journal of the Renin-Angiotensin-Aldosterone System
Online Access:	https://doi.org/10.1177/1470320318759358

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