Kinetics of IgG antibody to cytomegalovirus (CMV) after birth and seroprevalence of anti-CMV IgG in Chinese children
<p>Abstract</p> <p>Background</p> <p>Prevalence of cytomegalovirus (CMV) infection is 90–100% in developing countries; however, the kinetics of anti-CMV IgG in infants remains elusive.</p> <p>Methods</p> <p>Sera from 112 mother-newborn pairs and...
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BMC
2012-12-01
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| Series: | Virology Journal |
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| Online Access: | http://www.virologyj.com/content/9/1/304 |
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| author | Chen Jie Hu Lingqing Wu Meiling Zhong Tianying Zhou Yi-Hua Hu Yali |
| author_facet | Chen Jie Hu Lingqing Wu Meiling Zhong Tianying Zhou Yi-Hua Hu Yali |
| author_sort | Chen Jie |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Prevalence of cytomegalovirus (CMV) infection is 90–100% in developing countries; however, the kinetics of anti-CMV IgG in infants remains elusive.</p> <p>Methods</p> <p>Sera from 112 mother-newborn pairs and longitudinal samples from 41 infants up to 2-year old were tested for anti-CMV IgG and IgM. Additionally, samples from 837 healthy children were included.</p> <p>Results</p> <p>Of 112 mothers, 108 (96.4%) were anti-CMV IgG positive; their 108 newborns were also seropositive. In a 2-year follow-up among 40 infants of positive mothers, anti-CMV IgG level in 8 individuals decreased with time and became undetectable by age of 3.5–8 months, and that in 32 others decreased at 1- and 3.5-month old, and then increased. Based on the positive IgM, rising IgG levels, and low anti-CMV IgG avidity index, 76.7% of the primary infections were demonstrated to occur during 1–3.5 months of age. The overall seroprevalence of anti-CMV in 837 children was 82.4%, which was generally constant from 2 to 8 years old (χ<sup>2</sup> = 3.150, <it>p</it> = 0.790).</p> <p>Conclusions</p> <p>The maternally acquired anti-CMV IgG in infants disappears before 8-month old. Primary CMV infection in Chinese children mostly occurs during 1–3.5 months of age. Whether the relatively lower seroprevalence of anti-CMV in Chinese children found in this survey may reflect the positive rate in child-bearing age women in the future remains to be further studied.</p> |
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| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-20T00:10:14Z |
| publishDate | 2012-12-01 |
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| series | Virology Journal |
| spelling | doaj.art-f335e054e0fd43b290e9662b070a8f8d2022-12-21T20:00:31ZengBMCVirology Journal1743-422X2012-12-019130410.1186/1743-422X-9-304Kinetics of IgG antibody to cytomegalovirus (CMV) after birth and seroprevalence of anti-CMV IgG in Chinese childrenChen JieHu LingqingWu MeilingZhong TianyingZhou Yi-HuaHu Yali<p>Abstract</p> <p>Background</p> <p>Prevalence of cytomegalovirus (CMV) infection is 90–100% in developing countries; however, the kinetics of anti-CMV IgG in infants remains elusive.</p> <p>Methods</p> <p>Sera from 112 mother-newborn pairs and longitudinal samples from 41 infants up to 2-year old were tested for anti-CMV IgG and IgM. Additionally, samples from 837 healthy children were included.</p> <p>Results</p> <p>Of 112 mothers, 108 (96.4%) were anti-CMV IgG positive; their 108 newborns were also seropositive. In a 2-year follow-up among 40 infants of positive mothers, anti-CMV IgG level in 8 individuals decreased with time and became undetectable by age of 3.5–8 months, and that in 32 others decreased at 1- and 3.5-month old, and then increased. Based on the positive IgM, rising IgG levels, and low anti-CMV IgG avidity index, 76.7% of the primary infections were demonstrated to occur during 1–3.5 months of age. The overall seroprevalence of anti-CMV in 837 children was 82.4%, which was generally constant from 2 to 8 years old (χ<sup>2</sup> = 3.150, <it>p</it> = 0.790).</p> <p>Conclusions</p> <p>The maternally acquired anti-CMV IgG in infants disappears before 8-month old. Primary CMV infection in Chinese children mostly occurs during 1–3.5 months of age. Whether the relatively lower seroprevalence of anti-CMV in Chinese children found in this survey may reflect the positive rate in child-bearing age women in the future remains to be further studied.</p>http://www.virologyj.com/content/9/1/304CytomegalovirusAnti-CMV IgGKineticsPrimary infectionChildren |
| spellingShingle | Chen Jie Hu Lingqing Wu Meiling Zhong Tianying Zhou Yi-Hua Hu Yali Kinetics of IgG antibody to cytomegalovirus (CMV) after birth and seroprevalence of anti-CMV IgG in Chinese children Virology Journal Cytomegalovirus Anti-CMV IgG Kinetics Primary infection Children |
| title | Kinetics of IgG antibody to cytomegalovirus (CMV) after birth and seroprevalence of anti-CMV IgG in Chinese children |
| title_full | Kinetics of IgG antibody to cytomegalovirus (CMV) after birth and seroprevalence of anti-CMV IgG in Chinese children |
| title_fullStr | Kinetics of IgG antibody to cytomegalovirus (CMV) after birth and seroprevalence of anti-CMV IgG in Chinese children |
| title_full_unstemmed | Kinetics of IgG antibody to cytomegalovirus (CMV) after birth and seroprevalence of anti-CMV IgG in Chinese children |
| title_short | Kinetics of IgG antibody to cytomegalovirus (CMV) after birth and seroprevalence of anti-CMV IgG in Chinese children |
| title_sort | kinetics of igg antibody to cytomegalovirus cmv after birth and seroprevalence of anti cmv igg in chinese children |
| topic | Cytomegalovirus Anti-CMV IgG Kinetics Primary infection Children |
| url | http://www.virologyj.com/content/9/1/304 |
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