Chemically modified aptamers for improving binding affinity to the target proteins via enhanced non-covalent bonding

Chemically modified aptamers for improving binding affinity to the target proteins via enhanced non-covalent bonding

Nucleic acid aptamers are ssDNA or ssRNA fragments that specifically recognize targets. However, the pharmacodynamic properties of natural aptamers consisting of 4 naturally occurring nucleosides (A, G, C, T/U) are generally restricted for inferior binding affinity than the cognate antibodies. The d...

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Bibliographic Details
Main Authors: Zefeng Chen, Hang Luo, Amu Gubu, Sifan Yu, Huarui Zhang, Hong Dai, Yihao Zhang, Baoting Zhang, Yuan Ma, Aiping Lu, Ge Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
aptamer
chemical modification
high affinity
non-covalent bonding
interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1091809/full

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