Long-Term Treatment of Streptozotocin-Induced Diabetes by Continuous Insulin Minipump in the Syrian Hamster
It is difficult to normalize plasma glucose for a prolonged period of time by SC injection in experimental animals. The goal of this study was to determine the feasibility and the dosage of insulin needed to maintain 24-h normoglycemia in streptozotocin-diabetic Syrian hamsters with a SC-implanted o...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
1999-09-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/096368979900800511 |
| _version_ | 1818134206128062464 |
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| author | William E. Fisher M.D. |
| author_facet | William E. Fisher M.D. |
| author_sort | William E. Fisher M.D. |
| collection | DOAJ |
| description | It is difficult to normalize plasma glucose for a prolonged period of time by SC injection in experimental animals. The goal of this study was to determine the feasibility and the dosage of insulin needed to maintain 24-h normoglycemia in streptozotocin-diabetic Syrian hamsters with a SC-implanted osmotic minipump. The pumps, which release insulin at a constant rate, were replaced every 14 days with fresh pumps for as long as 52 days. A high insulin dose (1 U/kg/h) was required to normalize plasma glucose and fatty acid concentrations, water and food consumption, urine output, and body weight. |
| first_indexed | 2024-12-11T09:04:56Z |
| format | Article |
| id | doaj.art-f33868c9a9374b0e8a9479564097965a |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-11T09:04:56Z |
| publishDate | 1999-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-f33868c9a9374b0e8a9479564097965a2022-12-22T01:13:39ZengSAGE PublishingCell Transplantation0963-68971555-38921999-09-01810.1177/096368979900800511Long-Term Treatment of Streptozotocin-Induced Diabetes by Continuous Insulin Minipump in the Syrian HamsterWilliam E. Fisher M.D.0Department of Surgery, Baylor College of Medicine, Houston, TXIt is difficult to normalize plasma glucose for a prolonged period of time by SC injection in experimental animals. The goal of this study was to determine the feasibility and the dosage of insulin needed to maintain 24-h normoglycemia in streptozotocin-diabetic Syrian hamsters with a SC-implanted osmotic minipump. The pumps, which release insulin at a constant rate, were replaced every 14 days with fresh pumps for as long as 52 days. A high insulin dose (1 U/kg/h) was required to normalize plasma glucose and fatty acid concentrations, water and food consumption, urine output, and body weight.https://doi.org/10.1177/096368979900800511 |
| spellingShingle | William E. Fisher M.D. Long-Term Treatment of Streptozotocin-Induced Diabetes by Continuous Insulin Minipump in the Syrian Hamster Cell Transplantation |
| title | Long-Term Treatment of Streptozotocin-Induced Diabetes by Continuous Insulin Minipump in the Syrian Hamster |
| title_full | Long-Term Treatment of Streptozotocin-Induced Diabetes by Continuous Insulin Minipump in the Syrian Hamster |
| title_fullStr | Long-Term Treatment of Streptozotocin-Induced Diabetes by Continuous Insulin Minipump in the Syrian Hamster |
| title_full_unstemmed | Long-Term Treatment of Streptozotocin-Induced Diabetes by Continuous Insulin Minipump in the Syrian Hamster |
| title_short | Long-Term Treatment of Streptozotocin-Induced Diabetes by Continuous Insulin Minipump in the Syrian Hamster |
| title_sort | long term treatment of streptozotocin induced diabetes by continuous insulin minipump in the syrian hamster |
| url | https://doi.org/10.1177/096368979900800511 |
| work_keys_str_mv | AT williamefishermd longtermtreatmentofstreptozotocininduceddiabetesbycontinuousinsulinminipumpinthesyrianhamster |