A Spontaneous Model of Experimental Autoimmune Encephalomyelitis Provides Evidence of MOG-Specific B Cell Recruitment and Clonal Expansion

A Spontaneous Model of Experimental Autoimmune Encephalomyelitis Provides Evidence of MOG-Specific B Cell Recruitment and Clonal Expansion

The key role of B cells in the pathophysiology of multiple sclerosis (MS) is supported by the presence of oligoclonal bands in the cerebrospinal fluid, by the association of meningeal ectopic B cell follicles with demyelination, axonal loss and reduction of astrocytes, as well as by the high efficac...

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Bibliographic Details
Main Authors: Florent Salvador, Laure Deramoudt, Frédéric Leprêtre, Martin Figeac, Thomas Guerrier, Julie Boucher, Mathilde Bas, Nathalie Journiac, Anneli Peters, Lennart T. Mars, Hélène Zéphir
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
B cell
repertoire
autoimmunity
experimental autoimmune encephalomyelitis (EAE)
multiple sclerosis
myelin oligodendrocyte glycoprotein (MOG)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.755900/full

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