Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators
Herpes stromal keratitis (HSK) is one of the primary diseases that cause vision loss or even blindness after herpes simplex virus (HSV)-1 infection. HSK-associated vision impairment is predominantly due to corneal scarring and neovascularization caused by inflammation. In the infected cornea, HSV ca...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00766/full |
| _version_ | 1818301403709308928 |
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| author | Li Wang Li Wang Runbiao Wang Chuyang Xu Hongyan Zhou |
| author_facet | Li Wang Li Wang Runbiao Wang Chuyang Xu Hongyan Zhou |
| author_sort | Li Wang |
| collection | DOAJ |
| description | Herpes stromal keratitis (HSK) is one of the primary diseases that cause vision loss or even blindness after herpes simplex virus (HSV)-1 infection. HSK-associated vision impairment is predominantly due to corneal scarring and neovascularization caused by inflammation. In the infected cornea, HSV can activate innate and adaptive immune responses of host cells, which triggers a cascade of reactions that leads to the release of inflammatory cytokines, chemokines, microRNA, and other regulatory factors that have stimulating or inhibitory effects on tissue. Physiologically, host cells show homeostasis. In this review, we summarize the factors involved in HSK pathogenesis from the perspective of immunity, molecules, and pathological angiogenesis. We also describe in detail the pathogenesis of chronic inflammatory lesions of the corneal stroma in response to HSV-1 infection. |
| first_indexed | 2024-12-13T05:22:28Z |
| format | Article |
| id | doaj.art-f33dbad1eaec411e97ddeab73e4f86df |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-13T05:22:28Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f33dbad1eaec411e97ddeab73e4f86df2022-12-21T23:58:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-05-011110.3389/fimmu.2020.00766531995Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory RegulatorsLi Wang0Li Wang1Runbiao Wang2Chuyang Xu3Hongyan Zhou4Department of Ophthalmology, China–Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Ophthalmology, Jilin City Central Hospital, Jilin, ChinaDepartment of Ophthalmology, Jilin City Central Hospital, Jilin, ChinaDepartment of Ophthalmology, China–Japan Union Hospital of Jilin University, Changchun, ChinaDepartment of Ophthalmology, China–Japan Union Hospital of Jilin University, Changchun, ChinaHerpes stromal keratitis (HSK) is one of the primary diseases that cause vision loss or even blindness after herpes simplex virus (HSV)-1 infection. HSK-associated vision impairment is predominantly due to corneal scarring and neovascularization caused by inflammation. In the infected cornea, HSV can activate innate and adaptive immune responses of host cells, which triggers a cascade of reactions that leads to the release of inflammatory cytokines, chemokines, microRNA, and other regulatory factors that have stimulating or inhibitory effects on tissue. Physiologically, host cells show homeostasis. In this review, we summarize the factors involved in HSK pathogenesis from the perspective of immunity, molecules, and pathological angiogenesis. We also describe in detail the pathogenesis of chronic inflammatory lesions of the corneal stroma in response to HSV-1 infection.https://www.frontiersin.org/article/10.3389/fimmu.2020.00766/fullstromal keratitisimmune responseherpes simplex virus (HSV-1)inflammationpathogenesis |
| spellingShingle | Li Wang Li Wang Runbiao Wang Chuyang Xu Hongyan Zhou Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators Frontiers in Immunology stromal keratitis immune response herpes simplex virus (HSV-1) inflammation pathogenesis |
| title | Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators |
| title_full | Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators |
| title_fullStr | Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators |
| title_full_unstemmed | Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators |
| title_short | Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators |
| title_sort | pathogenesis of herpes stromal keratitis immune inflammatory response mediated by inflammatory regulators |
| topic | stromal keratitis immune response herpes simplex virus (HSV-1) inflammation pathogenesis |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00766/full |
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