The effects of high-sensitivity C-reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off-pump coronary artery bypass grafting
Abstract Purpose To investigate the relationship between obstructive sleep apnea (OSA) severity and high-sensitivity C-reactive protein (Hs-CRP), and their respective impact on the clinical outcomes in patients undergoing off-pump cardiac artery bypass grafting (OPCABG). Methods We enrolled consecut...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-07-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-021-02168-2 |
| _version_ | 1818652405439397888 |
|---|---|
| author | Mingxin Gao Kangjun Fan Wenyuan Yu Hongli Liu Yongxiang Wei Yang Yu |
| author_facet | Mingxin Gao Kangjun Fan Wenyuan Yu Hongli Liu Yongxiang Wei Yang Yu |
| author_sort | Mingxin Gao |
| collection | DOAJ |
| description | Abstract Purpose To investigate the relationship between obstructive sleep apnea (OSA) severity and high-sensitivity C-reactive protein (Hs-CRP), and their respective impact on the clinical outcomes in patients undergoing off-pump cardiac artery bypass grafting (OPCABG). Methods We enrolled consecutive eligible patients listed for elective OPCABG who underwent cardiorespiratory polygraphy before surgery between January 2019 and December 2019 in this prospective observational single-center study. Baseline, intraoperative, and postoperative clinical data were compared between absent-mild and moderate-severe OSA groups. Regression analysis investigated the relationship between Hs-CRP level and severity of OSA, and further assessed the factors influencing postoperative atrial fibrillation, duration of hospitalization, and hospital cost. Results Patients with moderate-severe OSA accounted for 42.3% (52/123) of the cohort. Partial pressure of carbon dioxide (PCO2), Hs-CRP, apnea hypopnea index (AHI), mean apnea time, maximum apnea time, and oxygen desaturation index ODI ≥ 3% were significantly higher in the moderate-severe OSA group than in the absent-mild OSA group. Left ventricle ejection fraction (LVEF), lowest arterial oxygen saturation (SaO2), and mean SaO2 were significantly lower in the moderate-severe OSA group. Moderate-severe OSA was associated with elevated Hs-CRP level (OR = 2.356, 95% CI 1.101–5.041, P = 0.027). Hs-CRP was an independent risk factor for post-CABG atrial fibrillation (POAF) (OR = 1.212, P = 0.01). Hs-CRP level independently correlated with duration of hospitalization (B = 0.456, P = 0.001) and hospital cost (B = 1.111, P = 0.044). Conclusion Hs-CRP level was closely related to OSA severity and have potential utility in predicting POAF, duration of hospitalization, and hospital costs in patients undergoing OPCABG. |
| first_indexed | 2024-12-17T02:21:29Z |
| format | Article |
| id | doaj.art-f3401d6088a04102af2f4cbc63a5fb18 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-17T02:21:29Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-f3401d6088a04102af2f4cbc63a5fb182022-12-21T22:07:15ZengBMCBMC Cardiovascular Disorders1471-22612021-07-0121111010.1186/s12872-021-02168-2The effects of high-sensitivity C-reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off-pump coronary artery bypass graftingMingxin Gao0Kangjun Fan1Wenyuan Yu2Hongli Liu3Yongxiang Wei4Yang Yu5Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Otolaryngology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical UniversityAbstract Purpose To investigate the relationship between obstructive sleep apnea (OSA) severity and high-sensitivity C-reactive protein (Hs-CRP), and their respective impact on the clinical outcomes in patients undergoing off-pump cardiac artery bypass grafting (OPCABG). Methods We enrolled consecutive eligible patients listed for elective OPCABG who underwent cardiorespiratory polygraphy before surgery between January 2019 and December 2019 in this prospective observational single-center study. Baseline, intraoperative, and postoperative clinical data were compared between absent-mild and moderate-severe OSA groups. Regression analysis investigated the relationship between Hs-CRP level and severity of OSA, and further assessed the factors influencing postoperative atrial fibrillation, duration of hospitalization, and hospital cost. Results Patients with moderate-severe OSA accounted for 42.3% (52/123) of the cohort. Partial pressure of carbon dioxide (PCO2), Hs-CRP, apnea hypopnea index (AHI), mean apnea time, maximum apnea time, and oxygen desaturation index ODI ≥ 3% were significantly higher in the moderate-severe OSA group than in the absent-mild OSA group. Left ventricle ejection fraction (LVEF), lowest arterial oxygen saturation (SaO2), and mean SaO2 were significantly lower in the moderate-severe OSA group. Moderate-severe OSA was associated with elevated Hs-CRP level (OR = 2.356, 95% CI 1.101–5.041, P = 0.027). Hs-CRP was an independent risk factor for post-CABG atrial fibrillation (POAF) (OR = 1.212, P = 0.01). Hs-CRP level independently correlated with duration of hospitalization (B = 0.456, P = 0.001) and hospital cost (B = 1.111, P = 0.044). Conclusion Hs-CRP level was closely related to OSA severity and have potential utility in predicting POAF, duration of hospitalization, and hospital costs in patients undergoing OPCABG.https://doi.org/10.1186/s12872-021-02168-2Obstructive sleep apneaHigh-sensitivity C-reactive proteinClinical outcomesOff-pump cardiac artery bypass grafting |
| spellingShingle | Mingxin Gao Kangjun Fan Wenyuan Yu Hongli Liu Yongxiang Wei Yang Yu The effects of high-sensitivity C-reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off-pump coronary artery bypass grafting BMC Cardiovascular Disorders Obstructive sleep apnea High-sensitivity C-reactive protein Clinical outcomes Off-pump cardiac artery bypass grafting |
| title | The effects of high-sensitivity C-reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off-pump coronary artery bypass grafting |
| title_full | The effects of high-sensitivity C-reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off-pump coronary artery bypass grafting |
| title_fullStr | The effects of high-sensitivity C-reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off-pump coronary artery bypass grafting |
| title_full_unstemmed | The effects of high-sensitivity C-reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off-pump coronary artery bypass grafting |
| title_short | The effects of high-sensitivity C-reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off-pump coronary artery bypass grafting |
| title_sort | effects of high sensitivity c reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off pump coronary artery bypass grafting |
| topic | Obstructive sleep apnea High-sensitivity C-reactive protein Clinical outcomes Off-pump cardiac artery bypass grafting |
| url | https://doi.org/10.1186/s12872-021-02168-2 |
| work_keys_str_mv | AT mingxingao theeffectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting AT kangjunfan theeffectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting AT wenyuanyu theeffectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting AT hongliliu theeffectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting AT yongxiangwei theeffectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting AT yangyu theeffectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting AT mingxingao effectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting AT kangjunfan effectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting AT wenyuanyu effectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting AT hongliliu effectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting AT yongxiangwei effectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting AT yangyu effectsofhighsensitivitycreactiveproteinontheclinicaloutcomesinobstructivesleepapneapatientsundergoingoffpumpcoronaryarterybypassgrafting |