The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.
Influenza A viruses (IAV) bind to sialic-acids at cellular surfaces and enter cells by using endocytotic routes. There is evidence that this process does not occur constitutively but requires induction of specific cellular signals, including activation of PI3K that promotes virus internalization. Th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-09-01
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| Series: | PLoS Pathogens |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20844577/?tool=EBI |
| _version_ | 1818722130764759040 |
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| author | Thorsten Eierhoff Eike R Hrincius Ursula Rescher Stephan Ludwig Christina Ehrhardt |
| author_facet | Thorsten Eierhoff Eike R Hrincius Ursula Rescher Stephan Ludwig Christina Ehrhardt |
| author_sort | Thorsten Eierhoff |
| collection | DOAJ |
| description | Influenza A viruses (IAV) bind to sialic-acids at cellular surfaces and enter cells by using endocytotic routes. There is evidence that this process does not occur constitutively but requires induction of specific cellular signals, including activation of PI3K that promotes virus internalization. This implies engagement of cellular signaling receptors during viral entry. Here, we present first indications for an interplay of IAV with receptor tyrosine kinases (RTKs). As representative RTK family-members the epidermal growth factor receptor (EGFR) and the c-Met receptor were studied. Modulation of expression or activity of both RTKs resulted in altered uptake of IAV, showing that these receptors transmit entry relevant signals upon virus binding. More detailed studies on EGFR function revealed that virus binding lead to clustering of lipid-rafts, suggesting that multivalent binding of IAV to cells induces a signaling platform leading to activation of EGFR and other RTKs that in turn facilitates IAV uptake. |
| first_indexed | 2024-12-17T20:49:44Z |
| format | Article |
| id | doaj.art-f340d3cdb4194ef8a93e14a4fea5ca59 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-17T20:49:44Z |
| publishDate | 2010-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-f340d3cdb4194ef8a93e14a4fea5ca592022-12-21T21:33:04ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742010-09-0169e100109910.1371/journal.ppat.1001099The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells.Thorsten EierhoffEike R HrinciusUrsula RescherStephan LudwigChristina EhrhardtInfluenza A viruses (IAV) bind to sialic-acids at cellular surfaces and enter cells by using endocytotic routes. There is evidence that this process does not occur constitutively but requires induction of specific cellular signals, including activation of PI3K that promotes virus internalization. This implies engagement of cellular signaling receptors during viral entry. Here, we present first indications for an interplay of IAV with receptor tyrosine kinases (RTKs). As representative RTK family-members the epidermal growth factor receptor (EGFR) and the c-Met receptor were studied. Modulation of expression or activity of both RTKs resulted in altered uptake of IAV, showing that these receptors transmit entry relevant signals upon virus binding. More detailed studies on EGFR function revealed that virus binding lead to clustering of lipid-rafts, suggesting that multivalent binding of IAV to cells induces a signaling platform leading to activation of EGFR and other RTKs that in turn facilitates IAV uptake.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20844577/?tool=EBI |
| spellingShingle | Thorsten Eierhoff Eike R Hrincius Ursula Rescher Stephan Ludwig Christina Ehrhardt The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. PLoS Pathogens |
| title | The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. |
| title_full | The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. |
| title_fullStr | The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. |
| title_full_unstemmed | The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. |
| title_short | The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. |
| title_sort | epidermal growth factor receptor egfr promotes uptake of influenza a viruses iav into host cells |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20844577/?tool=EBI |
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