Segmentation and morphological analysis of amyloid fibrils from cryo-EM image data

Segmentation and morphological analysis of amyloid fibrils from cryo-EM image data

Abstract Fast assessment of the composition of amyloid fibril samples from cryo-EM data poses a serious challenge to existing image analysis tools. We develop a method for automated segmentation of single fibrils requiring only little user input during the training process. This is achieved by combi...

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Bibliographic Details
Main Authors: Matthias Weber, Matthias Neumann, Matthias Schmidt, Peter Benedikt Pfeiffer, Akanksha Bansal, Marcus Fändrich, Volker Schmidt
Format: Article
Language:English
Published: SpringerOpen 2023-02-01
Series:Journal of Mathematics in Industry
Subjects:
Cryo-EM image data
Amyloid fibril
Cross-over distance
Fibril width
Single-object segmentation
Convolutional neural network
Online Access:https://doi.org/10.1186/s13362-023-00131-8

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