Associative role of methylenetetrahydrofolate reductase and thymidylate synthase 6bp del gene polymorphism in preterm delivery
Objective: Preterm delivery is a major adverse birth outcome, approximately 15 million babies are born prematurely every year. There are several causes for preterm deliveries. This study focuses on folate metabolic pathways. Dietary folate plays a crucial role in premature labor. We examined the re...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | MGM Journal of Medical Sciences |
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| Online Access: | http://www.mgmjms.com/article.asp?issn=2347-7946;year=2023;volume=10;issue=1;spage=77;epage=84;aulast=Panikar |
| _version_ | 1797773716364460032 |
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| author | Surya AS Panikar Sunil Sharma Krishna Sureshkumar Shubhangi Dubey Mansee Kapil Thakur |
| author_facet | Surya AS Panikar Sunil Sharma Krishna Sureshkumar Shubhangi Dubey Mansee Kapil Thakur |
| author_sort | Surya AS Panikar |
| collection | DOAJ |
| description | Objective: Preterm delivery is a major adverse birth outcome, approximately 15 million babies are born prematurely every year. There are several causes for preterm deliveries. This study focuses on folate metabolic pathways. Dietary folate plays a crucial role in premature labor. We examined the relationship between methylenetetrahydrofolate reductase (MTHFR) (C677T) and thymidylate synthase (TYMS) 6bpdel polymorphism. Materials and Methods: A total number of 300 pregnant women were selected for this study; among which (n = 150) were preterm and (n = 150) were term delivery cases. The selected samples were further processed for molecular polymerase chain reaction-restriction fragment length polymorphism analysis. The demographic profile of birth status resulted significantly with (P = 0.0001) proving chances of high infant mortality due to prematurity. Results: The genotype distribution of MTHFR C677T showed significant data (P = 0.0021) whereas insignificant genotypic distribution was observed for the TYMS gene (P = 0.067). Our results imply that genes that are involved in the folate pathway play a crucial role in early pregnancy. Conclusion: Advanced and better strategies can be brought to an improved intervention of folate at the time of pregnancy which will help to reduce the rate of premature deliveries. |
| first_indexed | 2024-03-12T22:10:30Z |
| format | Article |
| id | doaj.art-f3431224debf4ee3a8a7e0a6a2dfc7c9 |
| institution | Directory Open Access Journal |
| issn | 2347-7946 2347-7962 |
| language | English |
| last_indexed | 2024-03-12T22:10:30Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | MGM Journal of Medical Sciences |
| spelling | doaj.art-f3431224debf4ee3a8a7e0a6a2dfc7c92023-07-23T16:09:31ZengWolters Kluwer Medknow PublicationsMGM Journal of Medical Sciences2347-79462347-79622023-01-01101778410.4103/mgmj.mgmj_220_22Associative role of methylenetetrahydrofolate reductase and thymidylate synthase 6bp del gene polymorphism in preterm deliverySurya AS PanikarSunil SharmaKrishna SureshkumarShubhangi DubeyMansee Kapil ThakurObjective: Preterm delivery is a major adverse birth outcome, approximately 15 million babies are born prematurely every year. There are several causes for preterm deliveries. This study focuses on folate metabolic pathways. Dietary folate plays a crucial role in premature labor. We examined the relationship between methylenetetrahydrofolate reductase (MTHFR) (C677T) and thymidylate synthase (TYMS) 6bpdel polymorphism. Materials and Methods: A total number of 300 pregnant women were selected for this study; among which (n = 150) were preterm and (n = 150) were term delivery cases. The selected samples were further processed for molecular polymerase chain reaction-restriction fragment length polymorphism analysis. The demographic profile of birth status resulted significantly with (P = 0.0001) proving chances of high infant mortality due to prematurity. Results: The genotype distribution of MTHFR C677T showed significant data (P = 0.0021) whereas insignificant genotypic distribution was observed for the TYMS gene (P = 0.067). Our results imply that genes that are involved in the folate pathway play a crucial role in early pregnancy. Conclusion: Advanced and better strategies can be brought to an improved intervention of folate at the time of pregnancy which will help to reduce the rate of premature deliveries.http://www.mgmjms.com/article.asp?issn=2347-7946;year=2023;volume=10;issue=1;spage=77;epage=84;aulast=Panikarpcr-rflppolymorphismpreterm delivery |
| spellingShingle | Surya AS Panikar Sunil Sharma Krishna Sureshkumar Shubhangi Dubey Mansee Kapil Thakur Associative role of methylenetetrahydrofolate reductase and thymidylate synthase 6bp del gene polymorphism in preterm delivery MGM Journal of Medical Sciences pcr-rflp polymorphism preterm delivery |
| title | Associative role of methylenetetrahydrofolate reductase and thymidylate synthase 6bp del gene polymorphism in preterm delivery |
| title_full | Associative role of methylenetetrahydrofolate reductase and thymidylate synthase 6bp del gene polymorphism in preterm delivery |
| title_fullStr | Associative role of methylenetetrahydrofolate reductase and thymidylate synthase 6bp del gene polymorphism in preterm delivery |
| title_full_unstemmed | Associative role of methylenetetrahydrofolate reductase and thymidylate synthase 6bp del gene polymorphism in preterm delivery |
| title_short | Associative role of methylenetetrahydrofolate reductase and thymidylate synthase 6bp del gene polymorphism in preterm delivery |
| title_sort | associative role of methylenetetrahydrofolate reductase and thymidylate synthase 6bp del gene polymorphism in preterm delivery |
| topic | pcr-rflp polymorphism preterm delivery |
| url | http://www.mgmjms.com/article.asp?issn=2347-7946;year=2023;volume=10;issue=1;spage=77;epage=84;aulast=Panikar |
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