Neuroinflammation: Microglia and T Cells Get Ready to Tango
In recent years, many paradigms concerning central nervous system (CNS) immunology have been challenged and shifted, including the discovery of CNS-draining lymphatic vessels, the origin and functional diversity of microglia, the impact of T cells on CNS immunological homeostasis and the role of neu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01905/full |
| _version_ | 1811221443466231808 |
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| author | Sjoerd T. T. Schetters Diego Gomez-Nicola Juan J. Garcia-Vallejo Yvette Van Kooyk |
| author_facet | Sjoerd T. T. Schetters Diego Gomez-Nicola Juan J. Garcia-Vallejo Yvette Van Kooyk |
| author_sort | Sjoerd T. T. Schetters |
| collection | DOAJ |
| description | In recent years, many paradigms concerning central nervous system (CNS) immunology have been challenged and shifted, including the discovery of CNS-draining lymphatic vessels, the origin and functional diversity of microglia, the impact of T cells on CNS immunological homeostasis and the role of neuroinflammation in neurodegenerative diseases. In parallel, antigen presentation outside the CNS has revealed the vital role of antigen-presenting cells in maintaining tolerance toward self-proteins, thwarting auto-immunity. Here, we review recent findings that unite these shifted paradigms of microglial functioning, antigen presentation, and CNS-directed T cell activation, focusing on common neurodegenerative diseases. It provides an important update on CNS adaptive immunity, novel targets, and a concept of the microglia T-cell equilibrium. |
| first_indexed | 2024-04-12T08:00:26Z |
| format | Article |
| id | doaj.art-f344877f88fa4e55911224f42bb063c5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T08:00:26Z |
| publishDate | 2018-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f344877f88fa4e55911224f42bb063c52022-12-22T03:41:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-01-01810.3389/fimmu.2017.01905294587Neuroinflammation: Microglia and T Cells Get Ready to TangoSjoerd T. T. Schetters0Diego Gomez-Nicola1Juan J. Garcia-Vallejo2Yvette Van Kooyk3Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, NetherlandsCentre for Biological Sciences, University of Southampton, Southampton, United KingdomDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, NetherlandsDepartment of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, NetherlandsIn recent years, many paradigms concerning central nervous system (CNS) immunology have been challenged and shifted, including the discovery of CNS-draining lymphatic vessels, the origin and functional diversity of microglia, the impact of T cells on CNS immunological homeostasis and the role of neuroinflammation in neurodegenerative diseases. In parallel, antigen presentation outside the CNS has revealed the vital role of antigen-presenting cells in maintaining tolerance toward self-proteins, thwarting auto-immunity. Here, we review recent findings that unite these shifted paradigms of microglial functioning, antigen presentation, and CNS-directed T cell activation, focusing on common neurodegenerative diseases. It provides an important update on CNS adaptive immunity, novel targets, and a concept of the microglia T-cell equilibrium.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01905/fullT cellsmicrogliatolerancecentral nervous systemantigen presentationinflammation |
| spellingShingle | Sjoerd T. T. Schetters Diego Gomez-Nicola Juan J. Garcia-Vallejo Yvette Van Kooyk Neuroinflammation: Microglia and T Cells Get Ready to Tango Frontiers in Immunology T cells microglia tolerance central nervous system antigen presentation inflammation |
| title | Neuroinflammation: Microglia and T Cells Get Ready to Tango |
| title_full | Neuroinflammation: Microglia and T Cells Get Ready to Tango |
| title_fullStr | Neuroinflammation: Microglia and T Cells Get Ready to Tango |
| title_full_unstemmed | Neuroinflammation: Microglia and T Cells Get Ready to Tango |
| title_short | Neuroinflammation: Microglia and T Cells Get Ready to Tango |
| title_sort | neuroinflammation microglia and t cells get ready to tango |
| topic | T cells microglia tolerance central nervous system antigen presentation inflammation |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01905/full |
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