Medical Relevance, State-of-the-Art and Perspectives of “Sweet Metacode” in Liquid Biopsy Approaches
This review briefly introduces readers to an area where glycomics meets modern oncodiagnostics with a focus on the analysis of sialic acid (Neu5Ac)-terminated structures. We present the biochemical perspective of aberrant sialylation during tumourigenesis and its significance, as well as an analytic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/14/7/713 |
| _version_ | 1797212815391457280 |
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| author | Andrea Pinkeova Natalia Kosutova Eduard Jane Lenka Lorencova Aniko Bertokova Tomas Bertok Jan Tkac |
| author_facet | Andrea Pinkeova Natalia Kosutova Eduard Jane Lenka Lorencova Aniko Bertokova Tomas Bertok Jan Tkac |
| author_sort | Andrea Pinkeova |
| collection | DOAJ |
| description | This review briefly introduces readers to an area where glycomics meets modern oncodiagnostics with a focus on the analysis of sialic acid (Neu5Ac)-terminated structures. We present the biochemical perspective of aberrant sialylation during tumourigenesis and its significance, as well as an analytical perspective on the detection of these structures using different approaches for diagnostic and therapeutic purposes. We also provide a comparison to other established liquid biopsy approaches, and we mathematically define an early-stage cancer based on the overall prognosis and effect of these approaches on the patient’s quality of life. Finally, some barriers including regulations and quality of clinical validations data are discussed, and a perspective and major challenges in this area are summarised. |
| first_indexed | 2024-04-24T10:48:23Z |
| format | Article |
| id | doaj.art-f344bfa74fcd4a69aa7730d87f35122c |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-24T10:48:23Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f344bfa74fcd4a69aa7730d87f35122c2024-04-12T13:16:46ZengMDPI AGDiagnostics2075-44182024-03-0114771310.3390/diagnostics14070713Medical Relevance, State-of-the-Art and Perspectives of “Sweet Metacode” in Liquid Biopsy ApproachesAndrea Pinkeova0Natalia Kosutova1Eduard Jane2Lenka Lorencova3Aniko Bertokova4Tomas Bertok5Jan Tkac6Institute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, SlovakiaInstitute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, SlovakiaInstitute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, SlovakiaInstitute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, SlovakiaGlycanostics, Ltd., Kudlakova 7, 841 08 Bratislava, SlovakiaInstitute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, SlovakiaInstitute of Chemistry, Slovak Academy of Sciences, Dubravska cesta 9, 845 38 Bratislava, SlovakiaThis review briefly introduces readers to an area where glycomics meets modern oncodiagnostics with a focus on the analysis of sialic acid (Neu5Ac)-terminated structures. We present the biochemical perspective of aberrant sialylation during tumourigenesis and its significance, as well as an analytical perspective on the detection of these structures using different approaches for diagnostic and therapeutic purposes. We also provide a comparison to other established liquid biopsy approaches, and we mathematically define an early-stage cancer based on the overall prognosis and effect of these approaches on the patient’s quality of life. Finally, some barriers including regulations and quality of clinical validations data are discussed, and a perspective and major challenges in this area are summarised.https://www.mdpi.com/2075-4418/14/7/713cancerglycansialic aciddiagnosticsliquid biopsy |
| spellingShingle | Andrea Pinkeova Natalia Kosutova Eduard Jane Lenka Lorencova Aniko Bertokova Tomas Bertok Jan Tkac Medical Relevance, State-of-the-Art and Perspectives of “Sweet Metacode” in Liquid Biopsy Approaches Diagnostics cancer glycan sialic acid diagnostics liquid biopsy |
| title | Medical Relevance, State-of-the-Art and Perspectives of “Sweet Metacode” in Liquid Biopsy Approaches |
| title_full | Medical Relevance, State-of-the-Art and Perspectives of “Sweet Metacode” in Liquid Biopsy Approaches |
| title_fullStr | Medical Relevance, State-of-the-Art and Perspectives of “Sweet Metacode” in Liquid Biopsy Approaches |
| title_full_unstemmed | Medical Relevance, State-of-the-Art and Perspectives of “Sweet Metacode” in Liquid Biopsy Approaches |
| title_short | Medical Relevance, State-of-the-Art and Perspectives of “Sweet Metacode” in Liquid Biopsy Approaches |
| title_sort | medical relevance state of the art and perspectives of sweet metacode in liquid biopsy approaches |
| topic | cancer glycan sialic acid diagnostics liquid biopsy |
| url | https://www.mdpi.com/2075-4418/14/7/713 |
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