#52 : Cumulative Live Birth Rates (CLBR) According to the Number of Oocytes Retrieved in Minimal Stimulation In Vitro Fertilization (IVF) Treatment
Background and Aims: Ovarian stimulation is necessary for IVF in order to stimulate the development of multiple follicles in a single cycle. To optimize ovarian stimulation, there is a need to know the optimum number of oocytes retrieved to achieve a live birth. This retrospective study aimed to eva...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
World Scientific Publishing
2023-12-01
|
| Series: | Fertility & Reproduction |
| Online Access: | https://www.worldscientific.com/doi/10.1142/S2661318223741474 |
| _version_ | 1797237032448163840 |
|---|---|
| author | Ednalyn Ong-Jao Rudie Frederick Mendiola Gayla Perillo Fides Marie Francisco |
| author_facet | Ednalyn Ong-Jao Rudie Frederick Mendiola Gayla Perillo Fides Marie Francisco |
| author_sort | Ednalyn Ong-Jao |
| collection | DOAJ |
| description | Background and Aims: Ovarian stimulation is necessary for IVF in order to stimulate the development of multiple follicles in a single cycle. To optimize ovarian stimulation, there is a need to know the optimum number of oocytes retrieved to achieve a live birth. This retrospective study aimed to evaluate the relationship between the number of oocytes retrieved and the cumulative live birth rates among patients undergoing mild stimulation IVF treatment in a private fertility clinic in the Philippines. Method: Ovulation was induced using clomiphene citrate in combination with lower doses of gonadotropins. Final oocyte maturation was triggered with hCG or GnRHa. Mature eggs were fertilized using intracytoplasmic sperm injection. Only 1 to 2 embryos were transferred per cycle. Results: A total of 1,431 patients that had 1,817 fresh and frozen transfer cycles were included. Average age of women was 35.70 ± 3.97 (min. 20, max. 46). Binary logistic regression shows that age is a predictor of live birth, with a critical value of 34.6 years. CLBR was estimated using Kaplan-Meier survival analysis, with the number of oocytes as the time factor. The estimated mean number of oocytes retrieved for cases that had live birth was 8.90 ± 0.30. Half of the cases that had live birth had an estimated oocyte number of 7.0 ± 0.194. Live birth steadily increased with the number of oocytes but declined beyond 25 oocytes. Retrieval of 6 to 9 oocytes was enough to achieve 40-60% CLBR. In comparison, conventional IVF recommends 8 to 15 oocytes to achieve similar CLBR. Conclusion: Retrieval of lower numbers of oocytes with minimal stimulation IVF can produce desirable success rates comparable to rates achieved with higher numbers of retrieved oocytes in conventional IVF. |
| first_indexed | 2024-04-24T17:13:18Z |
| format | Article |
| id | doaj.art-f3450c5df74041a4aec5f24acf007a48 |
| institution | Directory Open Access Journal |
| issn | 2661-3182 2661-3174 |
| language | English |
| last_indexed | 2024-04-24T17:13:18Z |
| publishDate | 2023-12-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Fertility & Reproduction |
| spelling | doaj.art-f3450c5df74041a4aec5f24acf007a482024-03-28T07:54:19ZengWorld Scientific PublishingFertility & Reproduction2661-31822661-31742023-12-01050433933910.1142/S2661318223741474#52 : Cumulative Live Birth Rates (CLBR) According to the Number of Oocytes Retrieved in Minimal Stimulation In Vitro Fertilization (IVF) TreatmentEdnalyn Ong-Jao0Rudie Frederick Mendiola1Gayla Perillo2Fides Marie Francisco3Kato Repro Biotech Center, Makati, PhilippinesKato Repro Biotech Center, Makati, PhilippinesKato Repro Biotech Center, Makati, PhilippinesKato Repro Biotech Center, Makati, PhilippinesBackground and Aims: Ovarian stimulation is necessary for IVF in order to stimulate the development of multiple follicles in a single cycle. To optimize ovarian stimulation, there is a need to know the optimum number of oocytes retrieved to achieve a live birth. This retrospective study aimed to evaluate the relationship between the number of oocytes retrieved and the cumulative live birth rates among patients undergoing mild stimulation IVF treatment in a private fertility clinic in the Philippines. Method: Ovulation was induced using clomiphene citrate in combination with lower doses of gonadotropins. Final oocyte maturation was triggered with hCG or GnRHa. Mature eggs were fertilized using intracytoplasmic sperm injection. Only 1 to 2 embryos were transferred per cycle. Results: A total of 1,431 patients that had 1,817 fresh and frozen transfer cycles were included. Average age of women was 35.70 ± 3.97 (min. 20, max. 46). Binary logistic regression shows that age is a predictor of live birth, with a critical value of 34.6 years. CLBR was estimated using Kaplan-Meier survival analysis, with the number of oocytes as the time factor. The estimated mean number of oocytes retrieved for cases that had live birth was 8.90 ± 0.30. Half of the cases that had live birth had an estimated oocyte number of 7.0 ± 0.194. Live birth steadily increased with the number of oocytes but declined beyond 25 oocytes. Retrieval of 6 to 9 oocytes was enough to achieve 40-60% CLBR. In comparison, conventional IVF recommends 8 to 15 oocytes to achieve similar CLBR. Conclusion: Retrieval of lower numbers of oocytes with minimal stimulation IVF can produce desirable success rates comparable to rates achieved with higher numbers of retrieved oocytes in conventional IVF.https://www.worldscientific.com/doi/10.1142/S2661318223741474 |
| spellingShingle | Ednalyn Ong-Jao Rudie Frederick Mendiola Gayla Perillo Fides Marie Francisco #52 : Cumulative Live Birth Rates (CLBR) According to the Number of Oocytes Retrieved in Minimal Stimulation In Vitro Fertilization (IVF) Treatment Fertility & Reproduction |
| title | #52 : Cumulative Live Birth Rates (CLBR) According to the Number of Oocytes Retrieved in Minimal Stimulation In Vitro Fertilization (IVF) Treatment |
| title_full | #52 : Cumulative Live Birth Rates (CLBR) According to the Number of Oocytes Retrieved in Minimal Stimulation In Vitro Fertilization (IVF) Treatment |
| title_fullStr | #52 : Cumulative Live Birth Rates (CLBR) According to the Number of Oocytes Retrieved in Minimal Stimulation In Vitro Fertilization (IVF) Treatment |
| title_full_unstemmed | #52 : Cumulative Live Birth Rates (CLBR) According to the Number of Oocytes Retrieved in Minimal Stimulation In Vitro Fertilization (IVF) Treatment |
| title_short | #52 : Cumulative Live Birth Rates (CLBR) According to the Number of Oocytes Retrieved in Minimal Stimulation In Vitro Fertilization (IVF) Treatment |
| title_sort | 52 cumulative live birth rates clbr according to the number of oocytes retrieved in minimal stimulation in vitro fertilization ivf treatment |
| url | https://www.worldscientific.com/doi/10.1142/S2661318223741474 |
| work_keys_str_mv | AT ednalynongjao 52cumulativelivebirthratesclbraccordingtothenumberofoocytesretrievedinminimalstimulationinvitrofertilizationivftreatment AT rudiefrederickmendiola 52cumulativelivebirthratesclbraccordingtothenumberofoocytesretrievedinminimalstimulationinvitrofertilizationivftreatment AT gaylaperillo 52cumulativelivebirthratesclbraccordingtothenumberofoocytesretrievedinminimalstimulationinvitrofertilizationivftreatment AT fidesmariefrancisco 52cumulativelivebirthratesclbraccordingtothenumberofoocytesretrievedinminimalstimulationinvitrofertilizationivftreatment |