Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report
Background Immune checkpoint inhibitors (ICIs) can induce a wide range of immune-related adverse events (irAEs), potentially affecting any organ. ICI-induced colitis is a frequently reported irAE, whereas enteritis is rare and not well documented.Case presentation We are presenting a patient with me...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-03-01
|
| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/9/1/e000989.full |
| _version_ | 1797785692778004480 |
|---|---|
| author | Jakob Benedict Seidelin Inge Marie Svane Eva Ellebaek Henrik Vedel Nielsen Emilie Kristine Dahl Morten Helms Rikke Boedker Holmstroem Jacob Tveiten Bjerrum Janne Bayer Andersen |
| author_facet | Jakob Benedict Seidelin Inge Marie Svane Eva Ellebaek Henrik Vedel Nielsen Emilie Kristine Dahl Morten Helms Rikke Boedker Holmstroem Jacob Tveiten Bjerrum Janne Bayer Andersen |
| author_sort | Jakob Benedict Seidelin |
| collection | DOAJ |
| description | Background Immune checkpoint inhibitors (ICIs) can induce a wide range of immune-related adverse events (irAEs), potentially affecting any organ. ICI-induced colitis is a frequently reported irAE, whereas enteritis is rare and not well documented.Case presentation We are presenting a patient with metastatic melanoma who developed severe ICI-induced enterocolitis multirefractory for glucocorticoids, infliximab and vedolizumab, partially responding to faecal microbiota transplantation and final complete response to tofacitinib.Conclusion This case supports that tofacitinib may be an(other) effective agent in managing multirefractory ICI-induced diarrhoea caused by colitis and/or enteritis. |
| first_indexed | 2024-03-13T00:57:37Z |
| format | Article |
| id | doaj.art-f345ce0c283a450c958e3063c09d7ea7 |
| institution | Directory Open Access Journal |
| issn | 2054-4774 |
| language | English |
| last_indexed | 2024-03-13T00:57:37Z |
| publishDate | 2022-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj.art-f345ce0c283a450c958e3063c09d7ea72023-07-06T18:30:07ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742022-03-019110.1136/bmjgast-2022-000989Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case reportJakob Benedict Seidelin0Inge Marie Svane1Eva Ellebaek2Henrik Vedel Nielsen3Emilie Kristine Dahl4Morten Helms5Rikke Boedker Holmstroem6Jacob Tveiten Bjerrum7Janne Bayer Andersen8Department of Gasteroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Herlev, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkAff1 grid.411900.d0000000406468325Center for Cancer Immune Therapy, Department of HaematologyCopenhagen University Hospital at Herlev Herlev DenmarkDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut, Kobenhavn, Denmark1Department of Medical Gastroenterology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmarkresearch fellowNational Center for Cancer Immunotherapy, Department of Oncology, Copenhagen University Hospital, Herlev, DenmarkDepartment of Gastroenterology, Copenhagen University Hospital, Herlev, DenmarkDepartment of Pathology, Copenhagen University Hospital, Herlev, DenmarkBackground Immune checkpoint inhibitors (ICIs) can induce a wide range of immune-related adverse events (irAEs), potentially affecting any organ. ICI-induced colitis is a frequently reported irAE, whereas enteritis is rare and not well documented.Case presentation We are presenting a patient with metastatic melanoma who developed severe ICI-induced enterocolitis multirefractory for glucocorticoids, infliximab and vedolizumab, partially responding to faecal microbiota transplantation and final complete response to tofacitinib.Conclusion This case supports that tofacitinib may be an(other) effective agent in managing multirefractory ICI-induced diarrhoea caused by colitis and/or enteritis.https://bmjopengastro.bmj.com/content/9/1/e000989.full |
| spellingShingle | Jakob Benedict Seidelin Inge Marie Svane Eva Ellebaek Henrik Vedel Nielsen Emilie Kristine Dahl Morten Helms Rikke Boedker Holmstroem Jacob Tveiten Bjerrum Janne Bayer Andersen Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report BMJ Open Gastroenterology |
| title | Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report |
| title_full | Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report |
| title_fullStr | Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report |
| title_full_unstemmed | Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report |
| title_short | Tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor-induced enterocolitis: case report |
| title_sort | tofacitinib and faecal microbiota transplantation in treating checkpoint inhibitor induced enterocolitis case report |
| url | https://bmjopengastro.bmj.com/content/9/1/e000989.full |
| work_keys_str_mv | AT jakobbenedictseidelin tofacitinibandfaecalmicrobiotatransplantationintreatingcheckpointinhibitorinducedenterocolitiscasereport AT ingemariesvane tofacitinibandfaecalmicrobiotatransplantationintreatingcheckpointinhibitorinducedenterocolitiscasereport AT evaellebaek tofacitinibandfaecalmicrobiotatransplantationintreatingcheckpointinhibitorinducedenterocolitiscasereport AT henrikvedelnielsen tofacitinibandfaecalmicrobiotatransplantationintreatingcheckpointinhibitorinducedenterocolitiscasereport AT emiliekristinedahl tofacitinibandfaecalmicrobiotatransplantationintreatingcheckpointinhibitorinducedenterocolitiscasereport AT mortenhelms tofacitinibandfaecalmicrobiotatransplantationintreatingcheckpointinhibitorinducedenterocolitiscasereport AT rikkeboedkerholmstroem tofacitinibandfaecalmicrobiotatransplantationintreatingcheckpointinhibitorinducedenterocolitiscasereport AT jacobtveitenbjerrum tofacitinibandfaecalmicrobiotatransplantationintreatingcheckpointinhibitorinducedenterocolitiscasereport AT jannebayerandersen tofacitinibandfaecalmicrobiotatransplantationintreatingcheckpointinhibitorinducedenterocolitiscasereport |