Insights Into the Role of Mitochondria in Vascular Calcification
Vascular calcification (VC) is a growing burden in aging societies worldwide, and with a significant increase in all-cause mortality and atherosclerotic plaque rupture, it is frequently found in patients with aging, diabetes, atherosclerosis, or chronic kidney disease. However, the mechanism of VC i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.879752/full |
| _version_ | 1818150534127812608 |
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| author | ZL Zeng ZL Zeng ZL Zeng Qing Yuan Qing Yuan Xuyu Zu Xuyu Zu Jianghua Liu Jianghua Liu |
| author_facet | ZL Zeng ZL Zeng ZL Zeng Qing Yuan Qing Yuan Xuyu Zu Xuyu Zu Jianghua Liu Jianghua Liu |
| author_sort | ZL Zeng |
| collection | DOAJ |
| description | Vascular calcification (VC) is a growing burden in aging societies worldwide, and with a significant increase in all-cause mortality and atherosclerotic plaque rupture, it is frequently found in patients with aging, diabetes, atherosclerosis, or chronic kidney disease. However, the mechanism of VC is still not yet fully understood, and there are still no effective therapies for VC. Regarding energy metabolism factories, mitochondria play a crucial role in maintaining vascular physiology. Discoveries in past decades signifying the role of mitochondrial homeostasis in normal physiology and pathological conditions led to tremendous advances in the field of VC. Therapies targeting basic mitochondrial processes, such as energy metabolism, damage in mitochondrial DNA, or free-radical generation, hold great promise. The remarkably unexplored field of the mitochondrial process has the potential to shed light on several VC-related diseases. This review focuses on current knowledge of mitochondrial dysfunction, dynamics anomalies, oxidative stress, and how it may relate to VC onset and progression and discusses the main challenges and prerequisites for their therapeutic applications. |
| first_indexed | 2024-12-11T13:24:27Z |
| format | Article |
| id | doaj.art-f3481a5d864148eda600220e1b5af16c |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-11T13:24:27Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-f3481a5d864148eda600220e1b5af16c2022-12-22T01:05:37ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-04-01910.3389/fcvm.2022.879752879752Insights Into the Role of Mitochondria in Vascular CalcificationZL Zeng0ZL Zeng1ZL Zeng2Qing Yuan3Qing Yuan4Xuyu Zu5Xuyu Zu6Jianghua Liu7Jianghua Liu8Department of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaDepartment of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaKey Laboratory for Arteriosclerology of Hunan Province, Department of Cardiovascular Disease, Hengyang Medical School, University of South China, Hengyang, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaDepartment of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaDepartment of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaDepartment of Metabolism and Endocrinology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaDepartment of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, ChinaVascular calcification (VC) is a growing burden in aging societies worldwide, and with a significant increase in all-cause mortality and atherosclerotic plaque rupture, it is frequently found in patients with aging, diabetes, atherosclerosis, or chronic kidney disease. However, the mechanism of VC is still not yet fully understood, and there are still no effective therapies for VC. Regarding energy metabolism factories, mitochondria play a crucial role in maintaining vascular physiology. Discoveries in past decades signifying the role of mitochondrial homeostasis in normal physiology and pathological conditions led to tremendous advances in the field of VC. Therapies targeting basic mitochondrial processes, such as energy metabolism, damage in mitochondrial DNA, or free-radical generation, hold great promise. The remarkably unexplored field of the mitochondrial process has the potential to shed light on several VC-related diseases. This review focuses on current knowledge of mitochondrial dysfunction, dynamics anomalies, oxidative stress, and how it may relate to VC onset and progression and discusses the main challenges and prerequisites for their therapeutic applications.https://www.frontiersin.org/articles/10.3389/fcvm.2022.879752/fullvascular calcificationmitochondriaoxidative stressextracellular vesicles (EVs)atherosclerosis |
| spellingShingle | ZL Zeng ZL Zeng ZL Zeng Qing Yuan Qing Yuan Xuyu Zu Xuyu Zu Jianghua Liu Jianghua Liu Insights Into the Role of Mitochondria in Vascular Calcification Frontiers in Cardiovascular Medicine vascular calcification mitochondria oxidative stress extracellular vesicles (EVs) atherosclerosis |
| title | Insights Into the Role of Mitochondria in Vascular Calcification |
| title_full | Insights Into the Role of Mitochondria in Vascular Calcification |
| title_fullStr | Insights Into the Role of Mitochondria in Vascular Calcification |
| title_full_unstemmed | Insights Into the Role of Mitochondria in Vascular Calcification |
| title_short | Insights Into the Role of Mitochondria in Vascular Calcification |
| title_sort | insights into the role of mitochondria in vascular calcification |
| topic | vascular calcification mitochondria oxidative stress extracellular vesicles (EVs) atherosclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.879752/full |
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