Attenuation of Yersinia pestis fyuA Mutants Caused by Iron Uptake Inhibition and Decreased Survivability in Macrophages

Attenuation of Yersinia pestis fyuA Mutants Caused by Iron Uptake Inhibition and Decreased Survivability in Macrophages

Yersinia pestis is the etiological agent of plague, a deadly infectious disease that has caused millions of deaths throughout history. Obtaining iron from the host is very important for bacterial pathogenicity. Y. pestis possesses many iron uptake systems. Yersiniabactin (Ybt) plays a major role in...

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Bibliographic Details
Main Authors: Yulu Chen, Kai Song, Xin Chen, Ye Li, Ruichen Lv, Qingwen Zhang, Yujun Cui, Yujing Bi, Yanping Han, Yafang Tan, Zongmin Du, Ruifu Yang, Zhizhen Qi, Yajun Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Yersinia pestis
iron uptake system
Ybt system
fyuA
virulence
pathogenicity
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.874773/full

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