Serum Lipid Profile in Pre and Post Cholecystectomy Patients
Introduction: Gall stones are common in western world with an incidence of 1.4 per 100 person per year. Based on evidence more than 50% of patients with gallstones have some sort of lipid disorder. Cholecystectomy causes redistribution of bile acid pool in the entero-hepatic circulation and inc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2017-04-01
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| Series: | International Journal of Anatomy Radiology and Surgery |
| Subjects: | |
| Online Access: | http://www.ijars.net/articles/PDF/2267/27123_CE[VSU]_F(GH)_PF1(VsuGH)_PFA(GH)_PF2(VsuGH).pdf |
| Summary: | Introduction: Gall stones are common in western world
with an incidence of 1.4 per 100 person per year. Based
on evidence more than 50% of patients with gallstones
have some sort of lipid disorder. Cholecystectomy causes
redistribution of bile acid pool in the entero-hepatic
circulation and increases the frequency of cycling cause
reduction in pool size thus exerting effect on lipid profile
decreasing total cholesterol and LDL cholesterol levels.
Aim: Evaluating lipid profile of patients with gall stone
pre- and post operatively on 7th day and one month and to
establish the effect of cholecystectomy on lipid profile.
Materials and Methods: This prospective observational
study included 60 patients of gall stones admitted to
Surgery Department of Rajindra Hospital Patiala from July
2014 to June 2016 and who underwent cholecystectomy.
The lipid profile was evaluated pre-operatively on the day
of operation and post operatively on 7th day and one month
after.
Results: The total serum lipid pre-operatively was
mean value of 553.47±140.86 mg% which increased to
562.58±103.17 mg% on the 7th day and then decreased
to 518.53±86.76 mg% one month post-operatively. Serum
triglycerides level increased initially to 159.47±43.32 mg%
on 7th day and then decreased significantly from mean
value of 143.63±69.05 mg% to 139.60±60 mg% one
month post-operatively. There was significant decrease
in total serum cholesterol from pre-operative mean
value of 193.17±58.84 mg% to 186.3±56.71 mg% on 7th
day and further decreased to 166.95±48.08 mg% one
month post-operatively. Total serum LDL cholesterol level
decreased significantly from pre-operative mean value of
153.90±43.44 mg% to 132.08±36.93 mg% on 7th day and
decreased further to 117.52±29.00 mg% one month post
operatively. The serum HDL cholesterol level increased
significantly from pre-operative level of 41.35±5.4 mg% to
43.27±6.3 mg% on 7th day and further to 54.10±8.5 mg%
one month post-operatively. Majority of patients had mixed
type of gall stones.
Conclusion: Total serum lipids, serum cholesterol, serum
LDL cholesterol and serum triglycerides levels decrease and
serum HDL cholesterol increase after cholecystectomy |
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| ISSN: | 2277-8543 2455-6874 |