Anti-Apoptotic Effects of Carotenoids in Neurodegeneration
Apoptosis, programmed cell death type I, is a critical part of neurodegeneration in cerebral ischemia, Parkinson’s, and Alzheimer’s disease. Apoptosis begins with activation of pro-death proteins Bax and Bak, release of cytochrome c and activation of caspases, loss of membrane integrity of intracell...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/15/3453 |
| _version_ | 1797560957474439168 |
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| author | Han-A Park Mary Margaret Hayden Sydni Bannerman Joseph Jansen Kristi M. Crowe-White |
| author_facet | Han-A Park Mary Margaret Hayden Sydni Bannerman Joseph Jansen Kristi M. Crowe-White |
| author_sort | Han-A Park |
| collection | DOAJ |
| description | Apoptosis, programmed cell death type I, is a critical part of neurodegeneration in cerebral ischemia, Parkinson’s, and Alzheimer’s disease. Apoptosis begins with activation of pro-death proteins Bax and Bak, release of cytochrome c and activation of caspases, loss of membrane integrity of intracellular organelles, and ultimately cell death. Approaches that block apoptotic pathways may prevent or delay neurodegenerative processes. Carotenoids are a group of pigments found in fruits, vegetables, and seaweeds that possess antioxidant properties. Over the last several decades, an increasing number of studies have demonstrated a protective role of carotenoids in neurodegenerative disease. In this review, we describe functions of commonly consumed carotenoids including lycopene, β-carotene, lutein, astaxanthin, and fucoxanthin and their roles in neurodegenerative disease models. We also discuss the underlying cellular mechanisms of carotenoid-mediated neuroprotection, including their antioxidant properties, role as signaling molecules, and as gene regulators that alleviate apoptosis-associated brain cell death. |
| first_indexed | 2024-03-10T18:07:41Z |
| format | Article |
| id | doaj.art-f34a57d0e8f943d29786eda68ed8bc20 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T18:07:41Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f34a57d0e8f943d29786eda68ed8bc202023-11-20T08:22:32ZengMDPI AGMolecules1420-30492020-07-012515345310.3390/molecules25153453Anti-Apoptotic Effects of Carotenoids in NeurodegenerationHan-A Park0Mary Margaret Hayden1Sydni Bannerman2Joseph Jansen3Kristi M. Crowe-White4Department of Human Nutrition and Hospitality Management, College of Human Environmental Sciences, The University of Alabama, Tuscaloosa, AL 35487, USADepartment of Human Nutrition and Hospitality Management, College of Human Environmental Sciences, The University of Alabama, Tuscaloosa, AL 35487, USADepartment of Human Nutrition and Hospitality Management, College of Human Environmental Sciences, The University of Alabama, Tuscaloosa, AL 35487, USADepartment of Human Nutrition and Hospitality Management, College of Human Environmental Sciences, The University of Alabama, Tuscaloosa, AL 35487, USADepartment of Human Nutrition and Hospitality Management, College of Human Environmental Sciences, The University of Alabama, Tuscaloosa, AL 35487, USAApoptosis, programmed cell death type I, is a critical part of neurodegeneration in cerebral ischemia, Parkinson’s, and Alzheimer’s disease. Apoptosis begins with activation of pro-death proteins Bax and Bak, release of cytochrome c and activation of caspases, loss of membrane integrity of intracellular organelles, and ultimately cell death. Approaches that block apoptotic pathways may prevent or delay neurodegenerative processes. Carotenoids are a group of pigments found in fruits, vegetables, and seaweeds that possess antioxidant properties. Over the last several decades, an increasing number of studies have demonstrated a protective role of carotenoids in neurodegenerative disease. In this review, we describe functions of commonly consumed carotenoids including lycopene, β-carotene, lutein, astaxanthin, and fucoxanthin and their roles in neurodegenerative disease models. We also discuss the underlying cellular mechanisms of carotenoid-mediated neuroprotection, including their antioxidant properties, role as signaling molecules, and as gene regulators that alleviate apoptosis-associated brain cell death.https://www.mdpi.com/1420-3049/25/15/3453apoptosismitochondriacarotenoidneurodegenerationantioxidant |
| spellingShingle | Han-A Park Mary Margaret Hayden Sydni Bannerman Joseph Jansen Kristi M. Crowe-White Anti-Apoptotic Effects of Carotenoids in Neurodegeneration Molecules apoptosis mitochondria carotenoid neurodegeneration antioxidant |
| title | Anti-Apoptotic Effects of Carotenoids in Neurodegeneration |
| title_full | Anti-Apoptotic Effects of Carotenoids in Neurodegeneration |
| title_fullStr | Anti-Apoptotic Effects of Carotenoids in Neurodegeneration |
| title_full_unstemmed | Anti-Apoptotic Effects of Carotenoids in Neurodegeneration |
| title_short | Anti-Apoptotic Effects of Carotenoids in Neurodegeneration |
| title_sort | anti apoptotic effects of carotenoids in neurodegeneration |
| topic | apoptosis mitochondria carotenoid neurodegeneration antioxidant |
| url | https://www.mdpi.com/1420-3049/25/15/3453 |
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