Differential Age-Related Declines in Cardiorespiratory Fitness Between People With and Without Type 2 Diabetes Mellitus
Objective: To assess the extent to which the established age-related decline in cardiorespiratory fitness (CRF) is augmented in adult men with type 2 diabetes mellitus (T2DM). Participants and Methods: This study used data from the Aerobics Center Longitudinal Study, conducted between September 18,...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542454821001016 |
| _version_ | 1818737658941145088 |
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| author | Andrew Ortaglia, MSPH, PhD Samantha M. McDonald, PhD Michael D. Wirth, MSPH, PhD Xuemei Sui, MD, MPH, PhD Matteo Bottai, ScD |
| author_facet | Andrew Ortaglia, MSPH, PhD Samantha M. McDonald, PhD Michael D. Wirth, MSPH, PhD Xuemei Sui, MD, MPH, PhD Matteo Bottai, ScD |
| author_sort | Andrew Ortaglia, MSPH, PhD |
| collection | DOAJ |
| description | Objective: To assess the extent to which the established age-related decline in cardiorespiratory fitness (CRF) is augmented in adult men with type 2 diabetes mellitus (T2DM). Participants and Methods: This study used data from the Aerobics Center Longitudinal Study, conducted between September 18, 1974, and August 3, 2006, in primarily non-Hispanic white, middle-to-upper class adults. The analyses were restricted to adult men with complete data on age, CRF, and T2DM (35,307 participants). Quantile regression models were used to estimate age-related differences in CRF, estimated using a maximal treadmill test, between persons with and without T2DM. Smoking status and birth cohort served as covariates. Results: Age-related declines in CRF were observed in men with and without T2DM. For men younger than 60 years, at low-mid percentiles of the CRF distribution the magnitude of the age-related decline in CRF was significantly higher (P-values=.00, .02) in men with T2DM than in those without T2DM. At upper percentiles, the decline with age between the 2 groups was virtually identical. Significant declines in CRF in men 45 years or younger were observed only at high levels of CRF for those without T2DM and at low levels of CRF for those with T2DM (P-values .00, .04). Conclusion: This study reported that men younger than 60 years with T2DM at the low-mid CRF percentiles experience an accelerated age-related decline in CRF. Men younger than 60 years with T2DM exhibiting high levels of CRF experienced a decline in CRF comparable to men without T2DM. This study highlights the importance of incorporating sufficient levels of exercise or activity to maintain high CRF in men with T2DM. |
| first_indexed | 2024-12-18T00:56:33Z |
| format | Article |
| id | doaj.art-f34c915b11824037a452f1518f68f5c1 |
| institution | Directory Open Access Journal |
| issn | 2542-4548 |
| language | English |
| last_indexed | 2024-12-18T00:56:33Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| spelling | doaj.art-f34c915b11824037a452f1518f68f5c12022-12-21T21:26:31ZengElsevierMayo Clinic Proceedings: Innovations, Quality & Outcomes2542-45482021-08-0154743752Differential Age-Related Declines in Cardiorespiratory Fitness Between People With and Without Type 2 Diabetes MellitusAndrew Ortaglia, MSPH, PhD0Samantha M. McDonald, PhD1Michael D. Wirth, MSPH, PhD2Xuemei Sui, MD, MPH, PhD3Matteo Bottai, ScD4Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia; Correspondence: Address to Andrew Ortaglia, MSPH, PhD, Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, 446 Discovery Bldg I, 915 Greene St, Columbia, SC.Department of Foundational Sciences and Research, School of Dental Medicine, East Carolina University, Greenville, NCDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia; College of Nursing, Cancer Prevention and Control Program, Arnold School of Public Health, University of South Carolina, ColumbiaDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, ColumbiaDivision of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, SwedenObjective: To assess the extent to which the established age-related decline in cardiorespiratory fitness (CRF) is augmented in adult men with type 2 diabetes mellitus (T2DM). Participants and Methods: This study used data from the Aerobics Center Longitudinal Study, conducted between September 18, 1974, and August 3, 2006, in primarily non-Hispanic white, middle-to-upper class adults. The analyses were restricted to adult men with complete data on age, CRF, and T2DM (35,307 participants). Quantile regression models were used to estimate age-related differences in CRF, estimated using a maximal treadmill test, between persons with and without T2DM. Smoking status and birth cohort served as covariates. Results: Age-related declines in CRF were observed in men with and without T2DM. For men younger than 60 years, at low-mid percentiles of the CRF distribution the magnitude of the age-related decline in CRF was significantly higher (P-values=.00, .02) in men with T2DM than in those without T2DM. At upper percentiles, the decline with age between the 2 groups was virtually identical. Significant declines in CRF in men 45 years or younger were observed only at high levels of CRF for those without T2DM and at low levels of CRF for those with T2DM (P-values .00, .04). Conclusion: This study reported that men younger than 60 years with T2DM at the low-mid CRF percentiles experience an accelerated age-related decline in CRF. Men younger than 60 years with T2DM exhibiting high levels of CRF experienced a decline in CRF comparable to men without T2DM. This study highlights the importance of incorporating sufficient levels of exercise or activity to maintain high CRF in men with T2DM.http://www.sciencedirect.com/science/article/pii/S2542454821001016 |
| spellingShingle | Andrew Ortaglia, MSPH, PhD Samantha M. McDonald, PhD Michael D. Wirth, MSPH, PhD Xuemei Sui, MD, MPH, PhD Matteo Bottai, ScD Differential Age-Related Declines in Cardiorespiratory Fitness Between People With and Without Type 2 Diabetes Mellitus Mayo Clinic Proceedings: Innovations, Quality & Outcomes |
| title | Differential Age-Related Declines in Cardiorespiratory Fitness Between People With and Without Type 2 Diabetes Mellitus |
| title_full | Differential Age-Related Declines in Cardiorespiratory Fitness Between People With and Without Type 2 Diabetes Mellitus |
| title_fullStr | Differential Age-Related Declines in Cardiorespiratory Fitness Between People With and Without Type 2 Diabetes Mellitus |
| title_full_unstemmed | Differential Age-Related Declines in Cardiorespiratory Fitness Between People With and Without Type 2 Diabetes Mellitus |
| title_short | Differential Age-Related Declines in Cardiorespiratory Fitness Between People With and Without Type 2 Diabetes Mellitus |
| title_sort | differential age related declines in cardiorespiratory fitness between people with and without type 2 diabetes mellitus |
| url | http://www.sciencedirect.com/science/article/pii/S2542454821001016 |
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