T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients

T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients

Type 1 diabetes mellitus (T1D) is an immune-mediated disease. The autoreactive T cells in T1D patients attack and destroy their own pancreatic cells. In order to systematically investigate the potential autoreactive T cell receptors (TCRs), we used a high-throughput immune repertoire sequencing tech...

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Bibliographic Details
Main Authors: Yin Tong, Zhoufang Li, Hua Zhang, Ligang Xia, Meng Zhang, Ying Xu, Zhanhui Wang, Michael W. Deem, Xiaojuan Sun, Jiankui He
Format: Article
Language:English
Published: Oxford University Press 2016-12-01
Series:Genomics, Proteomics & Bioinformatics
Subjects:
Diversity
High-throughput sequencing
Immune repertoire
T cell receptor
Type 1 diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S167202291630184X

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