Structural basis for sequence specific DNA binding and protein dimerization of HOXA13.

Structural basis for sequence specific DNA binding and protein dimerization of HOXA13.

The homeobox gene (HOXA13) codes for a transcription factor protein that binds to AT-rich DNA sequences and controls expression of genes during embryonic morphogenesis. Here we present the NMR structure of HOXA13 homeodomain (A13DBD) bound to an 11-mer DNA duplex. A13DBD forms a dimer that binds to...

Full description

Bibliographic Details
Main Authors: Yonghong Zhang, Christine A Larsen, H Scott Stadler, James B Ames
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3148250?pdf=render

Similar Items

Similar Items