Diethylcarbamazine, TRP channels and Ca2+ signaling in cells of the Ascaris intestine

Diethylcarbamazine, TRP channels and Ca2+ signaling in cells of the Ascaris intestine

Abstract The nematode parasite intestine absorbs nutrients, is involved in innate immunity, can metabolize xenobiotics and as we show here, is also a site of action of the anthelmintic, diethylcarbamazine. Diethylcarbamazine (DEC) is used to treat lymphatic filariasis and activates TRP-2, GON-2 &...

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Bibliographic Details
Main Authors: Paul D. E. Williams, Sudhanva S. Kashyap, Mark A. McHugh, Matthew T. Brewer, Alan P. Robertson, Richard J. Martin
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25648-7

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