A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study
PurposeLumbar disc herniation (LDH) is one of the leading causes of low-back pain and results in a series of clinical symptoms, including pain, reflex loss, and muscle weakness. Spinal manipulative therapy (SMT) can relieve pain and promote internal and external stabilization of the lumbar spine. In...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-09-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.974792/full |
| _version_ | 1797998820651433984 |
|---|---|
| author | Ya Wen Xiao-Min Chen Xin Jin Dong-Ya Ling Shao Chen Qin Huang Ning Kong Jin-Er Chai Qing Wang Mao-Sheng Xu Hong-Gen Du |
| author_facet | Ya Wen Xiao-Min Chen Xin Jin Dong-Ya Ling Shao Chen Qin Huang Ning Kong Jin-Er Chai Qing Wang Mao-Sheng Xu Hong-Gen Du |
| author_sort | Ya Wen |
| collection | DOAJ |
| description | PurposeLumbar disc herniation (LDH) is one of the leading causes of low-back pain and results in a series of clinical symptoms, including pain, reflex loss, and muscle weakness. Spinal manipulative therapy (SMT) can relieve pain and promote internal and external stabilization of the lumbar spine. In this study, we investigated whether the brain alterations of LDH patients with SMT were frequency-dependent based on the calculation of Amplitude of Low-Frequency Fluctuations (ALFF) and fractional ALFF (fALFF). Further, we established a cohort of LDH patients to evaluate the contribution of SMT treatments to brain functional reorganization.MethodsA total of 55 participants, including 27 LDH patients and 28 health controls (HCs), were collected. All LDH patients underwent two fMRI scans (before SMT and after the sixth SMT session). To represent LDH-related brain oscillatory activities, we calculated the ALFF and fALFF in the conventional band (0.01–0.08 Hz), the slow-4 band (0.027–0.073 Hz), and the slow-5 band (0.01–0.027 Hz). Moreover, we extracted ALFF and fALFF values in clusters with significant differences to evaluate the SMT effect.ResultsCompared with HCs, the LDH patients before SMT (LDH-pre) exhibited increased fALFF in right lingual gyri in the conventional band, and showed increased fALFF in left Cerebelum_Crus1 in the slow-4 band. We further examined the abnormal brain activities changes before and after the SMT intervention. The ALFF and fALFF values of LDH-pre group were higher than those of the HCs and LDH-pos groups. After SMT, the increased ALFF and fALFF values were suppressed for patients in conventional band and slow-4 band.ConclusionThe present study characterized the altered regional patterns in spontaneous neural activity in patients with LDH. Meanwhile, SMT is an effective treatment of LDH, and we supposed that it might have been involved in modulating dysfunctional brain regions which are important for the processing of pain. The findings of the current study may provide new insights to understand pathological mechanism of LDH. |
| first_indexed | 2024-04-11T10:54:48Z |
| format | Article |
| id | doaj.art-f35171073e134056bec75f73726a77c3 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-11T10:54:48Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-f35171073e134056bec75f73726a77c32022-12-22T04:28:48ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-09-011610.3389/fnins.2022.974792974792A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging studyYa Wen0Xiao-Min Chen1Xin Jin2Dong-Ya Ling3Shao Chen4Qin Huang5Ning Kong6Jin-Er Chai7Qing Wang8Mao-Sheng Xu9Hong-Gen Du10Department of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Radiology, Changshu No. 2 People’s Hospital, The Affiliated Changshu Hospital of Xuzhou Medical University, Changshu, ChinaDepartment of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaDepartment of Tuina, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaPurposeLumbar disc herniation (LDH) is one of the leading causes of low-back pain and results in a series of clinical symptoms, including pain, reflex loss, and muscle weakness. Spinal manipulative therapy (SMT) can relieve pain and promote internal and external stabilization of the lumbar spine. In this study, we investigated whether the brain alterations of LDH patients with SMT were frequency-dependent based on the calculation of Amplitude of Low-Frequency Fluctuations (ALFF) and fractional ALFF (fALFF). Further, we established a cohort of LDH patients to evaluate the contribution of SMT treatments to brain functional reorganization.MethodsA total of 55 participants, including 27 LDH patients and 28 health controls (HCs), were collected. All LDH patients underwent two fMRI scans (before SMT and after the sixth SMT session). To represent LDH-related brain oscillatory activities, we calculated the ALFF and fALFF in the conventional band (0.01–0.08 Hz), the slow-4 band (0.027–0.073 Hz), and the slow-5 band (0.01–0.027 Hz). Moreover, we extracted ALFF and fALFF values in clusters with significant differences to evaluate the SMT effect.ResultsCompared with HCs, the LDH patients before SMT (LDH-pre) exhibited increased fALFF in right lingual gyri in the conventional band, and showed increased fALFF in left Cerebelum_Crus1 in the slow-4 band. We further examined the abnormal brain activities changes before and after the SMT intervention. The ALFF and fALFF values of LDH-pre group were higher than those of the HCs and LDH-pos groups. After SMT, the increased ALFF and fALFF values were suppressed for patients in conventional band and slow-4 band.ConclusionThe present study characterized the altered regional patterns in spontaneous neural activity in patients with LDH. Meanwhile, SMT is an effective treatment of LDH, and we supposed that it might have been involved in modulating dysfunctional brain regions which are important for the processing of pain. The findings of the current study may provide new insights to understand pathological mechanism of LDH.https://www.frontiersin.org/articles/10.3389/fnins.2022.974792/fulllumbar disc herniationspinal manipulative therapyresting-state functional magnetic resonance imagingamplitude of low-frequency fluctuationsfrequency dependence |
| spellingShingle | Ya Wen Xiao-Min Chen Xin Jin Dong-Ya Ling Shao Chen Qin Huang Ning Kong Jin-Er Chai Qing Wang Mao-Sheng Xu Hong-Gen Du A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study Frontiers in Neuroscience lumbar disc herniation spinal manipulative therapy resting-state functional magnetic resonance imaging amplitude of low-frequency fluctuations frequency dependence |
| title | A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study |
| title_full | A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study |
| title_fullStr | A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study |
| title_full_unstemmed | A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study |
| title_short | A spinal manipulative therapy altered brain activity in patients with lumbar disc herniation: A resting-state functional magnetic resonance imaging study |
| title_sort | spinal manipulative therapy altered brain activity in patients with lumbar disc herniation a resting state functional magnetic resonance imaging study |
| topic | lumbar disc herniation spinal manipulative therapy resting-state functional magnetic resonance imaging amplitude of low-frequency fluctuations frequency dependence |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.974792/full |
| work_keys_str_mv | AT yawen aspinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT xiaominchen aspinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT xinjin aspinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT dongyaling aspinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT shaochen aspinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT qinhuang aspinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT ningkong aspinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT jinerchai aspinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT qingwang aspinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT maoshengxu aspinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT honggendu aspinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT yawen spinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT xiaominchen spinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT xinjin spinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT dongyaling spinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT shaochen spinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT qinhuang spinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT ningkong spinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT jinerchai spinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT qingwang spinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT maoshengxu spinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy AT honggendu spinalmanipulativetherapyalteredbrainactivityinpatientswithlumbardischerniationarestingstatefunctionalmagneticresonanceimagingstudy |