Justification of Chemotherapy Duration in Patients with Multiple and Pre-Extensive Drug Resistant Tuberculosis in the Russian Federation

Justification of Chemotherapy Duration in Patients with Multiple and Pre-Extensive Drug Resistant Tuberculosis in the Russian Federation

The objective: to justify the optimal duration of chemotherapy with Lzd and Bdq by evaluating the long-term treatment outcomes in patients with multiple/pre-extensive drug resistant (MDR/preXDR) tuberculosis who interrupted treatment at different time points.Subjects and Methods. 800 patients with M...

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Bibliographic Details
Main Authors: A. I. Gayda, A. V. Abramchenko, M. I. Romanova, T. V. Toichkina, V. S. Burykhin, S. E. Borisov, A. V. Filippov, T. A. Kuznetsova, D. V. Perkhin, O. M. Sveshnikova, M. V. Lekhlyayder, A. M. Panteleev, S. V. Toinova, T. I. Maslennikova, D. O. Galakhova, L. N. Populyashina, G. I. Saenko, E. S. Anisimova, A. K. Svicharskaya, N. A. Sosova, O. V. Lovacheva, A. O. Maryandyshev, A. G. Samoylova
Format: Article
Language:Russian
Published: New Terra Publishing House 2023-01-01
Series:Туберкулез и болезни лёгких
Subjects:
сроки лечения туберкулеза краткосрочные курсы химиотерапии
млу/прешлу-тб
линезолид и бедаквилин
Online Access:https://www.tibl-journal.com/jour/article/view/1700
Description
Summary:The objective: to justify the optimal duration of chemotherapy with Lzd and Bdq by evaluating the long-term treatment outcomes in patients with multiple/pre-extensive drug resistant (MDR/preXDR) tuberculosis who interrupted treatment at different time points.Subjects and Methods. 800 patients with MDR/preXDR tuberculosis were enrolled in the study, they were from all regions of the Russian Federation and they started a course of chemotherapy with regimens containing Lzd and Bdq in 2017-2018. All patients who interrupted their chemotherapy (124) were divided at 4 groups. Group 1-43 patients who received less than 90 doses, Group 2-37 patients who received from 91 to 180 doses, Group 3-39 patients who received from 181 to 270 doses, and Group 4-5 patients who received from 271 to 360 doses of anti-tuberculosis drugs.Results. In Group 3, the effectiveness of reaching a favorable outcome during observation for 3-4 years made 53.8% in 21/39, which was comparable to the effectiveness of treatment with a 24-month course of chemotherapy (2017 – 58.0 and 2018 – 52.1%). The treatment duration of patients from Group 3 was additionally analyzed, the arithmetic mean of the number of administered doses makes 262 ± 15, which allowed recommending 9-month courses of chemotherapy.
ISSN:2075-1230
2542-1506

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