Clinical value of the quantitation of average daily platelet increase during the recovery period in childhood acute lymphoblastic leukaemia
The time to platelet recovery (TPR) is becoming a predicting factor during the treatment of childhood acute leukaemia. However, the initial pre-treatment platelet count (PPC) could interfere with TPR. Here, we integrated both TPR and PPC as the average daily platelet amount increase (Ap) to predict...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-10-01
|
| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2018.1548011 |
| _version_ | 1797684238611382272 |
|---|---|
| author | Yuefang Wang Ge Zhang Lei Ye Qingkai Dai Luyun Peng Lan Chen Qi Chen Yongmei Jiang Ju Gao |
| author_facet | Yuefang Wang Ge Zhang Lei Ye Qingkai Dai Luyun Peng Lan Chen Qi Chen Yongmei Jiang Ju Gao |
| author_sort | Yuefang Wang |
| collection | DOAJ |
| description | The time to platelet recovery (TPR) is becoming a predicting factor during the treatment of childhood acute leukaemia. However, the initial pre-treatment platelet count (PPC) could interfere with TPR. Here, we integrated both TPR and PPC as the average daily platelet amount increase (Ap) to predict the prognosis in childhood B-ALL during the recovery period.148 patients were enrolled. The relationship between the Ap and MRD was evaluated, and Multivariate analysis was performed to evaluate whether Ap was independently associated with a better EFS. The PPC was inversely correlated with TPR (rs = −0.519, P = 0.021). Patients in Ap >3.9 × 109/L group had better EFS (x2 = 3.109, P = 0.028) than TPR ≤ 16d. Multivariate analysis indicated that Ap > 3.9 × 109/L was independently associated with a longer EFS (RR = 3.468; 95%CI: 1.037–11.597, P = 0.043). However, when introducing both MRD and Ap > 3.9 × 109/L as candidate variables, the Ap > 3.9 × 109/L lost its independent effect (P = 0.081). The strong association between MRD on treatment day 33 and Ap > 3.9 × 109/L (x2 = 148.00, P = 0.000) was responsible for this phenomenon. Ap could be a valuable prognostic indicator in childhood B-ALL. |
| first_indexed | 2024-03-12T00:27:43Z |
| format | Article |
| id | doaj.art-f3529b81d4994002b31379f424ea3b1e |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:27:43Z |
| publishDate | 2019-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-f3529b81d4994002b31379f424ea3b1e2023-09-15T10:32:00ZengTaylor & Francis GroupPlatelets0953-71041369-16352019-10-0130792392610.1080/09537104.2018.15480111548011Clinical value of the quantitation of average daily platelet increase during the recovery period in childhood acute lymphoblastic leukaemiaYuefang Wang0Ge Zhang1Lei Ye2Qingkai Dai3Luyun Peng4Lan Chen5Qi Chen6Yongmei Jiang7Ju Gao8Sichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversitySichuan UniversityThe time to platelet recovery (TPR) is becoming a predicting factor during the treatment of childhood acute leukaemia. However, the initial pre-treatment platelet count (PPC) could interfere with TPR. Here, we integrated both TPR and PPC as the average daily platelet amount increase (Ap) to predict the prognosis in childhood B-ALL during the recovery period.148 patients were enrolled. The relationship between the Ap and MRD was evaluated, and Multivariate analysis was performed to evaluate whether Ap was independently associated with a better EFS. The PPC was inversely correlated with TPR (rs = −0.519, P = 0.021). Patients in Ap >3.9 × 109/L group had better EFS (x2 = 3.109, P = 0.028) than TPR ≤ 16d. Multivariate analysis indicated that Ap > 3.9 × 109/L was independently associated with a longer EFS (RR = 3.468; 95%CI: 1.037–11.597, P = 0.043). However, when introducing both MRD and Ap > 3.9 × 109/L as candidate variables, the Ap > 3.9 × 109/L lost its independent effect (P = 0.081). The strong association between MRD on treatment day 33 and Ap > 3.9 × 109/L (x2 = 148.00, P = 0.000) was responsible for this phenomenon. Ap could be a valuable prognostic indicator in childhood B-ALL.http://dx.doi.org/10.1080/09537104.2018.1548011acute lymphoblastic leukaemiaaverage daily platelet amount increaseminimal residual diseaseplateletprognosis |
| spellingShingle | Yuefang Wang Ge Zhang Lei Ye Qingkai Dai Luyun Peng Lan Chen Qi Chen Yongmei Jiang Ju Gao Clinical value of the quantitation of average daily platelet increase during the recovery period in childhood acute lymphoblastic leukaemia Platelets acute lymphoblastic leukaemia average daily platelet amount increase minimal residual disease platelet prognosis |
| title | Clinical value of the quantitation of average daily platelet increase during the recovery period in childhood acute lymphoblastic leukaemia |
| title_full | Clinical value of the quantitation of average daily platelet increase during the recovery period in childhood acute lymphoblastic leukaemia |
| title_fullStr | Clinical value of the quantitation of average daily platelet increase during the recovery period in childhood acute lymphoblastic leukaemia |
| title_full_unstemmed | Clinical value of the quantitation of average daily platelet increase during the recovery period in childhood acute lymphoblastic leukaemia |
| title_short | Clinical value of the quantitation of average daily platelet increase during the recovery period in childhood acute lymphoblastic leukaemia |
| title_sort | clinical value of the quantitation of average daily platelet increase during the recovery period in childhood acute lymphoblastic leukaemia |
| topic | acute lymphoblastic leukaemia average daily platelet amount increase minimal residual disease platelet prognosis |
| url | http://dx.doi.org/10.1080/09537104.2018.1548011 |
| work_keys_str_mv | AT yuefangwang clinicalvalueofthequantitationofaveragedailyplateletincreaseduringtherecoveryperiodinchildhoodacutelymphoblasticleukaemia AT gezhang clinicalvalueofthequantitationofaveragedailyplateletincreaseduringtherecoveryperiodinchildhoodacutelymphoblasticleukaemia AT leiye clinicalvalueofthequantitationofaveragedailyplateletincreaseduringtherecoveryperiodinchildhoodacutelymphoblasticleukaemia AT qingkaidai clinicalvalueofthequantitationofaveragedailyplateletincreaseduringtherecoveryperiodinchildhoodacutelymphoblasticleukaemia AT luyunpeng clinicalvalueofthequantitationofaveragedailyplateletincreaseduringtherecoveryperiodinchildhoodacutelymphoblasticleukaemia AT lanchen clinicalvalueofthequantitationofaveragedailyplateletincreaseduringtherecoveryperiodinchildhoodacutelymphoblasticleukaemia AT qichen clinicalvalueofthequantitationofaveragedailyplateletincreaseduringtherecoveryperiodinchildhoodacutelymphoblasticleukaemia AT yongmeijiang clinicalvalueofthequantitationofaveragedailyplateletincreaseduringtherecoveryperiodinchildhoodacutelymphoblasticleukaemia AT jugao clinicalvalueofthequantitationofaveragedailyplateletincreaseduringtherecoveryperiodinchildhoodacutelymphoblasticleukaemia |