A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export.

A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export.

The assembly of ribosomal subunits in eukaryotes is a complex, multistep process so far mostly studied in yeast. In S. cerevisiae, more than 200 factors including ribosomal proteins and trans-acting factors are required for the ordered assembly of 40S and 60S ribosomal subunits. To date, only few hu...

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Bibliographic Details
Main Authors: Thomas Wild, Peter Horvath, Emanuel Wyler, Barbara Widmann, Lukas Badertscher, Ivo Zemp, Karol Kozak, Gabor Csucs, Elsebet Lund, Ulrike Kutay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2964341?pdf=render

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