A Framework for Ecotoxicity Testing in the 21st Century: Ecotox21
To reduce the considerable investments of toxicity testing and protecting animal welfare, a new toxicity testing strategy based on response pathways of human cell lines has been proposed in the United States to evaluate the chemical exposure risks to human health. However, the in vitro high-throughp...
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| Format: | Article |
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MDPI AG
2019-01-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/9/3/428 |
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| author | Zhen-guang Yan Xin Zheng Fu Gao Jun-tao Fan Shu-ping Wang Li-xin Yang |
| author_facet | Zhen-guang Yan Xin Zheng Fu Gao Jun-tao Fan Shu-ping Wang Li-xin Yang |
| author_sort | Zhen-guang Yan |
| collection | DOAJ |
| description | To reduce the considerable investments of toxicity testing and protecting animal welfare, a new toxicity testing strategy based on response pathways of human cell lines has been proposed in the United States to evaluate the chemical exposure risks to human health. However, the in vitro high-throughput assays have not yet been fully applied in ecotoxicity testing. This paper proposes a framework for high-efficiency ecotoxicity testing strategies to evaluate the ecological risk of chemicals. It consists of pathway-based toxicity testing, embryo-based toxicity testing, and predictive toxicology and data extrapolation, etc., according to different situations. The results of ecotoxicity testing or data mining are analyzed together with physicochemical properties, environmental fate, and exposure data of chemicals to conduct a comprehensive risk assessment of chemicals. The framework provides valuable points to establish high-efficiency ecotoxicity testing strategies in the 21st century. |
| first_indexed | 2024-12-10T11:11:01Z |
| format | Article |
| id | doaj.art-f353b654a9c041cf999797947aa3d945 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-12-10T11:11:01Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-f353b654a9c041cf999797947aa3d9452022-12-22T01:51:25ZengMDPI AGApplied Sciences2076-34172019-01-019342810.3390/app9030428app9030428A Framework for Ecotoxicity Testing in the 21st Century: Ecotox21Zhen-guang Yan0Xin Zheng1Fu Gao2Jun-tao Fan3Shu-ping Wang4Li-xin Yang5State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaState Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, ChinaTo reduce the considerable investments of toxicity testing and protecting animal welfare, a new toxicity testing strategy based on response pathways of human cell lines has been proposed in the United States to evaluate the chemical exposure risks to human health. However, the in vitro high-throughput assays have not yet been fully applied in ecotoxicity testing. This paper proposes a framework for high-efficiency ecotoxicity testing strategies to evaluate the ecological risk of chemicals. It consists of pathway-based toxicity testing, embryo-based toxicity testing, and predictive toxicology and data extrapolation, etc., according to different situations. The results of ecotoxicity testing or data mining are analyzed together with physicochemical properties, environmental fate, and exposure data of chemicals to conduct a comprehensive risk assessment of chemicals. The framework provides valuable points to establish high-efficiency ecotoxicity testing strategies in the 21st century.https://www.mdpi.com/2076-3417/9/3/428frameworkecotoxicity testinghigh-throughput assayecological risk assessment |
| spellingShingle | Zhen-guang Yan Xin Zheng Fu Gao Jun-tao Fan Shu-ping Wang Li-xin Yang A Framework for Ecotoxicity Testing in the 21st Century: Ecotox21 Applied Sciences framework ecotoxicity testing high-throughput assay ecological risk assessment |
| title | A Framework for Ecotoxicity Testing in the 21st Century: Ecotox21 |
| title_full | A Framework for Ecotoxicity Testing in the 21st Century: Ecotox21 |
| title_fullStr | A Framework for Ecotoxicity Testing in the 21st Century: Ecotox21 |
| title_full_unstemmed | A Framework for Ecotoxicity Testing in the 21st Century: Ecotox21 |
| title_short | A Framework for Ecotoxicity Testing in the 21st Century: Ecotox21 |
| title_sort | framework for ecotoxicity testing in the 21st century ecotox21 |
| topic | framework ecotoxicity testing high-throughput assay ecological risk assessment |
| url | https://www.mdpi.com/2076-3417/9/3/428 |
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