Effect of β-casomorphin-7 on intestinal mucosal immunity in aged mice
The immune deficiency caused by aging deserves attention, especially the weakening of intestinal mucosal immunity. The effect of β-casomorphin-7 on intestinal mucosal immunity was investigated in aged mice. Mice were treated without or with different doses of β-casomorphin-7 for 30 days. Histopathol...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2019-04-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=2514 |
| _version_ | 1797800744259158016 |
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| author | Hong YIN Ji-Jie LIU Dan YANG Hui-Qing XU |
| author_facet | Hong YIN Ji-Jie LIU Dan YANG Hui-Qing XU |
| author_sort | Hong YIN |
| collection | DOAJ |
| description | The immune deficiency caused by aging deserves attention, especially the weakening of intestinal mucosal immunity. The effect of
β-casomorphin-7 on intestinal mucosal immunity was investigated in aged mice. Mice were treated without or with different doses
of β-casomorphin-7 for 30 days. Histopathological studies showed the tissue protective role of β-casomorphin-7 in aged mice.
Low-dose group could significantly increase the level of IL-2 and TNF-α in intestinal mucosa. A significant increase in the level of
SIgA was observed in medium- and high-dose groups. The low and medium dose groups could significantly increase the activity of
SOD in small intestine mucosa. All dose groups significantly reduced the levels of MDA. The results suggest that β-casomorphin-7
could improve intestinal mucosal immune decline which is induced by aging The mechanisms for the regulating effects were likely
through balancing the cytokine level and controlling the oxidative stress. |
| first_indexed | 2024-03-13T04:38:52Z |
| format | Article |
| id | doaj.art-f35429c3baa84f1ab94c887c79442e9c |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:38:52Z |
| publishDate | 2019-04-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-f35429c3baa84f1ab94c887c79442e9c2023-06-19T06:34:12ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512019-04-0125568969610.9775/kvfd.2018.216282514Effect of β-casomorphin-7 on intestinal mucosal immunity in aged miceHong YIN0Ji-Jie LIU1Dan YANG2Hui-Qing XUDepartment of Nutrition, School of Tourism cooking & Food science and engineering, Yangzhou University, Yan 225000, CHINADepartment of Nutrition, School of Tourism cooking & Food science and engineering, Yangzhou University, Yan 225000, CHINADepartment of Nutrition, School of Tourism cooking & Food science and engineering, Yangzhou University, Yan 225000, CHINAThe immune deficiency caused by aging deserves attention, especially the weakening of intestinal mucosal immunity. The effect of β-casomorphin-7 on intestinal mucosal immunity was investigated in aged mice. Mice were treated without or with different doses of β-casomorphin-7 for 30 days. Histopathological studies showed the tissue protective role of β-casomorphin-7 in aged mice. Low-dose group could significantly increase the level of IL-2 and TNF-α in intestinal mucosa. A significant increase in the level of SIgA was observed in medium- and high-dose groups. The low and medium dose groups could significantly increase the activity of SOD in small intestine mucosa. All dose groups significantly reduced the levels of MDA. The results suggest that β-casomorphin-7 could improve intestinal mucosal immune decline which is induced by aging The mechanisms for the regulating effects were likely through balancing the cytokine level and controlling the oxidative stress.https://vetdergikafkas.org/pdf.php?id=2514β-casomorphin-7aging intestinal mucosal immune cytokineoxidative stress |
| spellingShingle | Hong YIN Ji-Jie LIU Dan YANG Hui-Qing XU Effect of β-casomorphin-7 on intestinal mucosal immunity in aged mice Kafkas Universitesi Veteriner Fakültesi Dergisi β-casomorphin-7 aging intestinal mucosal immune cytokine oxidative stress |
| title | Effect of β-casomorphin-7 on intestinal mucosal immunity in aged mice |
| title_full | Effect of β-casomorphin-7 on intestinal mucosal immunity in aged mice |
| title_fullStr | Effect of β-casomorphin-7 on intestinal mucosal immunity in aged mice |
| title_full_unstemmed | Effect of β-casomorphin-7 on intestinal mucosal immunity in aged mice |
| title_short | Effect of β-casomorphin-7 on intestinal mucosal immunity in aged mice |
| title_sort | effect of β casomorphin 7 on intestinal mucosal immunity in aged mice |
| topic | β-casomorphin-7 aging intestinal mucosal immune cytokine oxidative stress |
| url | https://vetdergikafkas.org/pdf.php?id=2514 |
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