Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial
Alzheimer’s disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-...
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| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1168549/full |
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| author | Patricio Solis-Urra Patricio Solis-Urra Patricio Solis-Urra Cristina Molina-Hidalgo Cristina Molina-Hidalgo Yolanda García-Rivero Yolanda García-Rivero Claudia Costa-Rodriguez Jose Mora-Gonzalez Beatriz Fernandez-Gamez Marcos Olvera-Rojas Andrea Coca-Pulido Angel Toval Darío Bellón Alessandro Sclafani Isabel Martín-Fuentes Eva María Triviño-Ibañez Eva María Triviño-Ibañez Carlos de Teresa Haiqing Huang George Grove Charles H. Hillman Charles H. Hillman Charles H. Hillman Arthur F. Kramer Arthur F. Kramer Andrés Catena Francisco B. Ortega Francisco B. Ortega Francisco B. Ortega Manuel Gómez-Río Manuel Gómez-Río Kirk I. Erickson Kirk I. Erickson Irene Esteban-Cornejo Irene Esteban-Cornejo Irene Esteban-Cornejo |
| author_facet | Patricio Solis-Urra Patricio Solis-Urra Patricio Solis-Urra Cristina Molina-Hidalgo Cristina Molina-Hidalgo Yolanda García-Rivero Yolanda García-Rivero Claudia Costa-Rodriguez Jose Mora-Gonzalez Beatriz Fernandez-Gamez Marcos Olvera-Rojas Andrea Coca-Pulido Angel Toval Darío Bellón Alessandro Sclafani Isabel Martín-Fuentes Eva María Triviño-Ibañez Eva María Triviño-Ibañez Carlos de Teresa Haiqing Huang George Grove Charles H. Hillman Charles H. Hillman Charles H. Hillman Arthur F. Kramer Arthur F. Kramer Andrés Catena Francisco B. Ortega Francisco B. Ortega Francisco B. Ortega Manuel Gómez-Río Manuel Gómez-Río Kirk I. Erickson Kirk I. Erickson Irene Esteban-Cornejo Irene Esteban-Cornejo Irene Esteban-Cornejo |
| author_sort | Patricio Solis-Urra |
| collection | DOAJ |
| description | Alzheimer’s disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. This single-site, two-arm, single-blinded, randomized controlled trial (RCT) will include 90 cognitively normal older adults, aged 65–80 years old. Participants will be randomized to a 24-week resistance exercise program (3 sessions/week, 60 min/session, n = 45), or a wait-list control group (n = 45) which will be asked to maintain their usual lifestyle. All study outcomes will be assessed at baseline and at 24-weeks after the exercise program, with a subset of selected outcomes assessed at 12-weeks. The primary outcome will be indicated by the change in an executive function composite score assessed with a comprehensive neuropsychological battery and the National Institutes of Health Toolbox Cognition Battery. Secondary outcomes will include changes in brain structure and function and amyloid deposition, other cognitive outcomes, and changes in molecular biomarkers assessed in blood, saliva, and fecal samples, physical function, muscular strength, body composition, mental health, and psychosocial parameters. We expect that the resistance exercise program will have positive effects on executive function and related brain structure and function, and will help to understand the molecular, structural, functional, and psychosocial mechanisms involved. |
| first_indexed | 2024-03-13T10:10:04Z |
| format | Article |
| id | doaj.art-f35549a0eca5445d97b4a06bc9fbdc32 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-03-13T10:10:04Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-f35549a0eca5445d97b4a06bc9fbdc322023-05-22T04:50:21ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612023-05-011710.3389/fnhum.2023.11685491168549Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trialPatricio Solis-Urra0Patricio Solis-Urra1Patricio Solis-Urra2Cristina Molina-Hidalgo3Cristina Molina-Hidalgo4Yolanda García-Rivero5Yolanda García-Rivero6Claudia Costa-Rodriguez7Jose Mora-Gonzalez8Beatriz Fernandez-Gamez9Marcos Olvera-Rojas10Andrea Coca-Pulido11Angel Toval12Darío Bellón13Alessandro Sclafani14Isabel Martín-Fuentes15Eva María Triviño-Ibañez16Eva María Triviño-Ibañez17Carlos de Teresa18Haiqing Huang19George Grove20Charles H. Hillman21Charles H. Hillman22Charles H. Hillman23Arthur F. Kramer24Arthur F. Kramer25Andrés Catena26Francisco B. Ortega27Francisco B. Ortega28Francisco B. Ortega29Manuel Gómez-Río30Manuel Gómez-Río31Kirk I. Erickson32Kirk I. Erickson33Irene Esteban-Cornejo34Irene Esteban-Cornejo35Irene Esteban-Cornejo36Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, SpainServicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, SpainFaculty of Education and Social Sciences, Universidad Andrés Bello, Viña del Mar, ChileDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, United StatesAdventHealth Research Institute, Neuroscience Institute, Orlando, FL, United StatesServicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spainibs.GRANADA Instituto de Investigación Biosanitaria, Granada, SpainDirección de Seleccion y Admisión de Alumnos, Universidad de Playa Ancha, Valparaíso, ChileDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, SpainDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, SpainDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, SpainDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, SpainDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, SpainDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, SpainDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, SpainDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, SpainServicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spainibs.GRANADA Instituto de Investigación Biosanitaria, Granada, SpainAndalusian Centre of Sports Medicine, Consejería de Turismo y Deporte, Granada, SpainDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, United StatesDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, United StatesCenter for Cognitive and Brain Health, Northeastern University, Boston, MA, United States0Department of Psychology, Northeastern University, Boston, MA, United States1Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, MA, United StatesCenter for Cognitive and Brain Health, Northeastern University, Boston, MA, United States2Beckman Institute, University of Illinois, Urbana, IL, United States3School of Psychology, University of Granada, Granada, SpainDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spain4Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland5Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, SpainServicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, Spainibs.GRANADA Instituto de Investigación Biosanitaria, Granada, SpainDepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, United StatesAdventHealth Research Institute, Neuroscience Institute, Orlando, FL, United StatesDepartment of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute, University of Granada, Granada, Spainibs.GRANADA Instituto de Investigación Biosanitaria, Granada, Spain5Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, SpainAlzheimer’s disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. This single-site, two-arm, single-blinded, randomized controlled trial (RCT) will include 90 cognitively normal older adults, aged 65–80 years old. Participants will be randomized to a 24-week resistance exercise program (3 sessions/week, 60 min/session, n = 45), or a wait-list control group (n = 45) which will be asked to maintain their usual lifestyle. All study outcomes will be assessed at baseline and at 24-weeks after the exercise program, with a subset of selected outcomes assessed at 12-weeks. The primary outcome will be indicated by the change in an executive function composite score assessed with a comprehensive neuropsychological battery and the National Institutes of Health Toolbox Cognition Battery. Secondary outcomes will include changes in brain structure and function and amyloid deposition, other cognitive outcomes, and changes in molecular biomarkers assessed in blood, saliva, and fecal samples, physical function, muscular strength, body composition, mental health, and psychosocial parameters. We expect that the resistance exercise program will have positive effects on executive function and related brain structure and function, and will help to understand the molecular, structural, functional, and psychosocial mechanisms involved.https://www.frontiersin.org/articles/10.3389/fnhum.2023.1168549/fullexerciseexecutive functionAlzheimer’s diseaseamyloid betabrain |
| spellingShingle | Patricio Solis-Urra Patricio Solis-Urra Patricio Solis-Urra Cristina Molina-Hidalgo Cristina Molina-Hidalgo Yolanda García-Rivero Yolanda García-Rivero Claudia Costa-Rodriguez Jose Mora-Gonzalez Beatriz Fernandez-Gamez Marcos Olvera-Rojas Andrea Coca-Pulido Angel Toval Darío Bellón Alessandro Sclafani Isabel Martín-Fuentes Eva María Triviño-Ibañez Eva María Triviño-Ibañez Carlos de Teresa Haiqing Huang George Grove Charles H. Hillman Charles H. Hillman Charles H. Hillman Arthur F. Kramer Arthur F. Kramer Andrés Catena Francisco B. Ortega Francisco B. Ortega Francisco B. Ortega Manuel Gómez-Río Manuel Gómez-Río Kirk I. Erickson Kirk I. Erickson Irene Esteban-Cornejo Irene Esteban-Cornejo Irene Esteban-Cornejo Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial Frontiers in Human Neuroscience exercise executive function Alzheimer’s disease amyloid beta brain |
| title | Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial |
| title_full | Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial |
| title_fullStr | Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial |
| title_full_unstemmed | Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial |
| title_short | Active Gains in brain Using Exercise During Aging (AGUEDA): protocol for a randomized controlled trial |
| title_sort | active gains in brain using exercise during aging agueda protocol for a randomized controlled trial |
| topic | exercise executive function Alzheimer’s disease amyloid beta brain |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1168549/full |
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