A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering
A new gelatin methacrylamine (GelMA)-poly (ethylene glycol) diacrylate (PEGDA)-nano hydroxyapatite (nHA) composite hydrogel scaffold was developed using UV photo-crosslinking technology. The Ca<sup>2+</sup> from nHA can form a [HO]Ca<sup>2+</sup> [OH] bridging structure with...
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/13/17/3735 |
| _version_ | 1797555995095859200 |
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| author | Yihu Wang Xiaofeng Cao Ming Ma Weipeng Lu Bing Zhang Yanchuan Guo |
| author_facet | Yihu Wang Xiaofeng Cao Ming Ma Weipeng Lu Bing Zhang Yanchuan Guo |
| author_sort | Yihu Wang |
| collection | DOAJ |
| description | A new gelatin methacrylamine (GelMA)-poly (ethylene glycol) diacrylate (PEGDA)-nano hydroxyapatite (nHA) composite hydrogel scaffold was developed using UV photo-crosslinking technology. The Ca<sup>2+</sup> from nHA can form a [HO]Ca<sup>2+</sup> [OH] bridging structure with the hydroxyl group in GelMA, thereby enhancing the stability. Compared with GelMA-PEGDA hydrogel, the addition of nHA can control the mechanical properties of the composite hydrogel and reduce the degradation rate. In vitro cell culture showed that osteoblast can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA-PEGDA-nHA hydrogel had good cell viability and biocompatibility. Furthermore, GelMA-PEGDA-nHA has excellent injectability and rapid prototyping properties and is a promising 3D printed bone repair scaffold material. |
| first_indexed | 2024-03-10T16:55:27Z |
| format | Article |
| id | doaj.art-f355a36e59ad4e5f8e163f988485ade8 |
| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T16:55:27Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-f355a36e59ad4e5f8e163f988485ade82023-11-20T11:10:26ZengMDPI AGMaterials1996-19442020-08-011317373510.3390/ma13173735A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue EngineeringYihu Wang0Xiaofeng Cao1Ming Ma2Weipeng Lu3Bing Zhang4Yanchuan Guo5Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaKey Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, ChinaA new gelatin methacrylamine (GelMA)-poly (ethylene glycol) diacrylate (PEGDA)-nano hydroxyapatite (nHA) composite hydrogel scaffold was developed using UV photo-crosslinking technology. The Ca<sup>2+</sup> from nHA can form a [HO]Ca<sup>2+</sup> [OH] bridging structure with the hydroxyl group in GelMA, thereby enhancing the stability. Compared with GelMA-PEGDA hydrogel, the addition of nHA can control the mechanical properties of the composite hydrogel and reduce the degradation rate. In vitro cell culture showed that osteoblast can adhere and proliferate on the surface of the hydrogel, indicating that the GelMA-PEGDA-nHA hydrogel had good cell viability and biocompatibility. Furthermore, GelMA-PEGDA-nHA has excellent injectability and rapid prototyping properties and is a promising 3D printed bone repair scaffold material.https://www.mdpi.com/1996-1944/13/17/3735hydrogelGelMAnHAphoto-crosslinking |
| spellingShingle | Yihu Wang Xiaofeng Cao Ming Ma Weipeng Lu Bing Zhang Yanchuan Guo A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering Materials hydrogel GelMA nHA photo-crosslinking |
| title | A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering |
| title_full | A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering |
| title_fullStr | A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering |
| title_full_unstemmed | A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering |
| title_short | A GelMA-PEGDA-nHA Composite Hydrogel for Bone Tissue Engineering |
| title_sort | gelma pegda nha composite hydrogel for bone tissue engineering |
| topic | hydrogel GelMA nHA photo-crosslinking |
| url | https://www.mdpi.com/1996-1944/13/17/3735 |
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