Aberrant information transfer interferes with functional axon regeneration
Functional axon regeneration requires regenerating neurons to restore appropriate synaptic connectivity and circuit function. To model this process, we developed an assay in Caenorhabditis elegans that links axon and synapse regeneration of a single neuron to recovery of behavior. After axon injury...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-10-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/38829 |
| _version_ | 1811181127177601024 |
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| author | Chen Ding Marc Hammarlund |
| author_facet | Chen Ding Marc Hammarlund |
| author_sort | Chen Ding |
| collection | DOAJ |
| description | Functional axon regeneration requires regenerating neurons to restore appropriate synaptic connectivity and circuit function. To model this process, we developed an assay in Caenorhabditis elegans that links axon and synapse regeneration of a single neuron to recovery of behavior. After axon injury and regeneration of the DA9 neuron, synapses reform at their pre-injury location. However, these regenerated synapses often lack key molecular components. Further, synaptic vesicles accumulate in the dendrite in response to axon injury. Dendritic vesicle release results in information misrouting that suppresses behavioral recovery. Dendritic synapse formation depends on dynein and jnk-1. But even when information transfer is corrected, axonal synapses fail to adequately transmit information. Our study reveals unexpected plasticity during functional regeneration. Regeneration of the axon is not sufficient for the reformation of correct neuronal circuits after injury. Rather, synapse reformation and function are also key variables, and manipulation of circuit reformation improves behavioral recovery. |
| first_indexed | 2024-04-11T09:14:26Z |
| format | Article |
| id | doaj.art-f355df39517944bcae807e3550cd847d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:14:26Z |
| publishDate | 2018-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-f355df39517944bcae807e3550cd847d2022-12-22T04:32:25ZengeLife Sciences Publications LtdeLife2050-084X2018-10-01710.7554/eLife.38829Aberrant information transfer interferes with functional axon regenerationChen Ding0Marc Hammarlund1https://orcid.org/0000-0002-3068-068XDepartment of Neuroscience, Yale University, New Haven, United StatesDepartment of Neuroscience, Yale University, New Haven, United States; Department of Genetics, Yale University, New Haven, United StatesFunctional axon regeneration requires regenerating neurons to restore appropriate synaptic connectivity and circuit function. To model this process, we developed an assay in Caenorhabditis elegans that links axon and synapse regeneration of a single neuron to recovery of behavior. After axon injury and regeneration of the DA9 neuron, synapses reform at their pre-injury location. However, these regenerated synapses often lack key molecular components. Further, synaptic vesicles accumulate in the dendrite in response to axon injury. Dendritic vesicle release results in information misrouting that suppresses behavioral recovery. Dendritic synapse formation depends on dynein and jnk-1. But even when information transfer is corrected, axonal synapses fail to adequately transmit information. Our study reveals unexpected plasticity during functional regeneration. Regeneration of the axon is not sufficient for the reformation of correct neuronal circuits after injury. Rather, synapse reformation and function are also key variables, and manipulation of circuit reformation improves behavioral recovery.https://elifesciences.org/articles/38829axon regenerationsynapse formationMAP kinase signalingDA9 neuronC. elegans |
| spellingShingle | Chen Ding Marc Hammarlund Aberrant information transfer interferes with functional axon regeneration eLife axon regeneration synapse formation MAP kinase signaling DA9 neuron C. elegans |
| title | Aberrant information transfer interferes with functional axon regeneration |
| title_full | Aberrant information transfer interferes with functional axon regeneration |
| title_fullStr | Aberrant information transfer interferes with functional axon regeneration |
| title_full_unstemmed | Aberrant information transfer interferes with functional axon regeneration |
| title_short | Aberrant information transfer interferes with functional axon regeneration |
| title_sort | aberrant information transfer interferes with functional axon regeneration |
| topic | axon regeneration synapse formation MAP kinase signaling DA9 neuron C. elegans |
| url | https://elifesciences.org/articles/38829 |
| work_keys_str_mv | AT chending aberrantinformationtransferinterfereswithfunctionalaxonregeneration AT marchammarlund aberrantinformationtransferinterfereswithfunctionalaxonregeneration |