Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment
Summary: Bipolar disorder (BD) is a common mental disorder characterized by manic and depressive episodes. Mood disorders have been associated with immune dysfunction. The combination of quetiapine and valproate has shown positive effects in treating BD, but the impact on immune dynamics remains les...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223011343 |
| _version_ | 1797774585312051200 |
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| author | Lingbin Qi Yan Qiu Sujuan Li Ning Yi Chanyi Li Ziwei Teng Shiping Li Xuelei Xu Bin Lang Jindong Chen Chunbing Zheng Yuan Yang Jiangzhou Hua Cheng Wang Haishan Wu Zhigang Xue Bo Lv |
| author_facet | Lingbin Qi Yan Qiu Sujuan Li Ning Yi Chanyi Li Ziwei Teng Shiping Li Xuelei Xu Bin Lang Jindong Chen Chunbing Zheng Yuan Yang Jiangzhou Hua Cheng Wang Haishan Wu Zhigang Xue Bo Lv |
| author_sort | Lingbin Qi |
| collection | DOAJ |
| description | Summary: Bipolar disorder (BD) is a common mental disorder characterized by manic and depressive episodes. Mood disorders have been associated with immune dysfunction. The combination of quetiapine and valproate has shown positive effects in treating BD, but the impact on immune dynamics remains less understood. Using single-cell RNA sequencing, we observed that B cells exhibited downregulation of inflammation-related genes, while pro-inflammatory mast and eosinophil cells decreased following treatment. Ribosomal peptide production genes were found to be reduced in both B and T cells after treatment. Additionally, our findings suggest that the combined therapy effectively alleviates inflammation by reducing myloid-mediated immune signaling pathways. This study provides valuable insights into the immune atlas and uncovers a potential mechanism for immune disorder alleviation in patients with BD treated with quetiapine and valproate. |
| first_indexed | 2024-03-12T22:23:14Z |
| format | Article |
| id | doaj.art-f357bfe2609441dd8062e9f52473b242 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-12T22:23:14Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-f357bfe2609441dd8062e9f52473b2422023-07-23T04:55:22ZengElsevieriScience2589-00422023-07-01267107057Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatmentLingbin Qi0Yan Qiu1Sujuan Li2Ning Yi3Chanyi Li4Ziwei Teng5Shiping Li6Xuelei Xu7Bin Lang8Jindong Chen9Chunbing Zheng10Yuan Yang11Jiangzhou Hua12Cheng Wang13Haishan Wu14Zhigang Xue15Bo Lv16Department of Regenerative Medicine, Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaDepartment of Regenerative Medicine, Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, ChinaDepartment of Regenerative Medicine, Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaStem Cell and Regenerative Medicine Engineering Research Center of Hunan Province, Hunan Yuanpin Cell Technology Co. Ltd, 102 Dongwu Road, Changsha City, Hunan Province 410100, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Department of Psychiatry, Xiangya Boai Rehabilitation Hospital, Changsha 410100, ChinaStem Cell and Regenerative Medicine Engineering Research Center of Hunan Province, Hunan Yuanpin Cell Technology Co. Ltd, 102 Dongwu Road, Changsha City, Hunan Province 410100, ChinaStem Cell and Regenerative Medicine Engineering Research Center of Hunan Province, Hunan Yuanpin Cell Technology Co. Ltd, 102 Dongwu Road, Changsha City, Hunan Province 410100, ChinaStem Cell and Regenerative Medicine Engineering Research Center of Hunan Province, Hunan Yuanpin Cell Technology Co. Ltd, 102 Dongwu Road, Changsha City, Hunan Province 410100, ChinaStem Cell and Regenerative Medicine Engineering Research Center of Hunan Province, Hunan Yuanpin Cell Technology Co. Ltd, 102 Dongwu Road, Changsha City, Hunan Province 410100, ChinaDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Corresponding authorDepartment of Regenerative Medicine, Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, China; Corresponding authorDepartment of Regenerative Medicine, Translational Center for Stem Cell Research, Tongji Hospital, Tongji University School of Medicine, Shanghai 200092, China; Corresponding authorSummary: Bipolar disorder (BD) is a common mental disorder characterized by manic and depressive episodes. Mood disorders have been associated with immune dysfunction. The combination of quetiapine and valproate has shown positive effects in treating BD, but the impact on immune dynamics remains less understood. Using single-cell RNA sequencing, we observed that B cells exhibited downregulation of inflammation-related genes, while pro-inflammatory mast and eosinophil cells decreased following treatment. Ribosomal peptide production genes were found to be reduced in both B and T cells after treatment. Additionally, our findings suggest that the combined therapy effectively alleviates inflammation by reducing myloid-mediated immune signaling pathways. This study provides valuable insights into the immune atlas and uncovers a potential mechanism for immune disorder alleviation in patients with BD treated with quetiapine and valproate.http://www.sciencedirect.com/science/article/pii/S2589004223011343Biological sciencesImmunologyOmicsTranscriptomics |
| spellingShingle | Lingbin Qi Yan Qiu Sujuan Li Ning Yi Chanyi Li Ziwei Teng Shiping Li Xuelei Xu Bin Lang Jindong Chen Chunbing Zheng Yuan Yang Jiangzhou Hua Cheng Wang Haishan Wu Zhigang Xue Bo Lv Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment iScience Biological sciences Immunology Omics Transcriptomics |
| title | Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment |
| title_full | Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment |
| title_fullStr | Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment |
| title_full_unstemmed | Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment |
| title_short | Single-cell immune profiling reveals broad anti-inflammation response in bipolar disorder patients with quetiapine and valproate treatment |
| title_sort | single cell immune profiling reveals broad anti inflammation response in bipolar disorder patients with quetiapine and valproate treatment |
| topic | Biological sciences Immunology Omics Transcriptomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223011343 |
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