Cancer and Diabetes: Predictive Factors in Patients with Metabolic Syndrome
Background and Objectives: A growing number of epidemiological studies have suggested that diabetes mellitus may increase cancer risk and is implicated in numerous other metabolic and inflammatory disorders. The increase in proinflammatory cytokines plays a major role in insulin resistance and leads...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/16/2647 |
| _version_ | 1797585083047084032 |
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| author | Mihai Cosmin Stan Daniel Georgescu Ciprian Camil Mireștean Florinel Bădulescu |
| author_facet | Mihai Cosmin Stan Daniel Georgescu Ciprian Camil Mireștean Florinel Bădulescu |
| author_sort | Mihai Cosmin Stan |
| collection | DOAJ |
| description | Background and Objectives: A growing number of epidemiological studies have suggested that diabetes mellitus may increase cancer risk and is implicated in numerous other metabolic and inflammatory disorders. The increase in proinflammatory cytokines plays a major role in insulin resistance and leads to hypoalbuminemia and micro- and macrovascular diabetes complications, including kidney disease and anemia. This study aimed to investigate the utility of carcinoembryonic antigen (CEA), C-reactive protein (CRP), serum albumin level, hemoglobin, and lactate dehydrogenase (LDH) as biomarkers for cancer risk, and the biological implications of diabetes on the evolution and prognosis of oncological patients. Material and Methods: We conducted a retrospective, longitudinal, observational study on a total group of 434 patients, of which 217 were diagnosed with a form of cancer and type two diabetes as a comorbidity, and the other 217 were a control group without diabetes. These patients were admitted to the oncology clinic. In subgroups, the same number of patients was considered, depending on the location of the oncological pathology. Anemia, hypoalbuminemia, elevated lactate dehydrogenase, glycated hemoglobin, and C-reactive protein levels are more pronounced in subjects with type two diabetes and cancer. Conclusions: The presence of diabetes negatively affects the clinical and biological prognosis of cancer patients. |
| first_indexed | 2024-03-11T00:00:45Z |
| format | Article |
| id | doaj.art-f3588f5e430641488603e154cb1aaa70 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T00:00:45Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f3588f5e430641488603e154cb1aaa702023-11-19T00:48:06ZengMDPI AGDiagnostics2075-44182023-08-011316264710.3390/diagnostics13162647Cancer and Diabetes: Predictive Factors in Patients with Metabolic SyndromeMihai Cosmin Stan0Daniel Georgescu1Ciprian Camil Mireștean2Florinel Bădulescu3Medical Oncology Department, Vâlcea Emergency County Hospital, 240156 Râmnicu Vâlcea, RomaniaDepartment of Informatics and Medical Statistics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaMedical Oncology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaMedical Oncology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, RomaniaBackground and Objectives: A growing number of epidemiological studies have suggested that diabetes mellitus may increase cancer risk and is implicated in numerous other metabolic and inflammatory disorders. The increase in proinflammatory cytokines plays a major role in insulin resistance and leads to hypoalbuminemia and micro- and macrovascular diabetes complications, including kidney disease and anemia. This study aimed to investigate the utility of carcinoembryonic antigen (CEA), C-reactive protein (CRP), serum albumin level, hemoglobin, and lactate dehydrogenase (LDH) as biomarkers for cancer risk, and the biological implications of diabetes on the evolution and prognosis of oncological patients. Material and Methods: We conducted a retrospective, longitudinal, observational study on a total group of 434 patients, of which 217 were diagnosed with a form of cancer and type two diabetes as a comorbidity, and the other 217 were a control group without diabetes. These patients were admitted to the oncology clinic. In subgroups, the same number of patients was considered, depending on the location of the oncological pathology. Anemia, hypoalbuminemia, elevated lactate dehydrogenase, glycated hemoglobin, and C-reactive protein levels are more pronounced in subjects with type two diabetes and cancer. Conclusions: The presence of diabetes negatively affects the clinical and biological prognosis of cancer patients.https://www.mdpi.com/2075-4418/13/16/2647diabetescanceranemiaalbumin |
| spellingShingle | Mihai Cosmin Stan Daniel Georgescu Ciprian Camil Mireștean Florinel Bădulescu Cancer and Diabetes: Predictive Factors in Patients with Metabolic Syndrome Diagnostics diabetes cancer anemia albumin |
| title | Cancer and Diabetes: Predictive Factors in Patients with Metabolic Syndrome |
| title_full | Cancer and Diabetes: Predictive Factors in Patients with Metabolic Syndrome |
| title_fullStr | Cancer and Diabetes: Predictive Factors in Patients with Metabolic Syndrome |
| title_full_unstemmed | Cancer and Diabetes: Predictive Factors in Patients with Metabolic Syndrome |
| title_short | Cancer and Diabetes: Predictive Factors in Patients with Metabolic Syndrome |
| title_sort | cancer and diabetes predictive factors in patients with metabolic syndrome |
| topic | diabetes cancer anemia albumin |
| url | https://www.mdpi.com/2075-4418/13/16/2647 |
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