Stereoselective OsO4-mediated dihydroxylation of β-substituted α-trialkylsilyl-β,γ-unsaturated esters

Stereoselective OsO4-mediated dihydroxylation of β-substituted α-trialkylsilyl-β,γ-unsaturated esters

The dihydroxylation of various of α-trialkylsilyl-β,γ-unsaturated esters with OsO4 and NMO has been explored. It has been revealed that these reactions readily allow for a stereoselective dihydroxylation with high levels of dr (>20/1) to afford anti-aldol products with three contiguous stereogeni...

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Bibliographic Details
Main Authors:	Anna C. Seal, Michael P. Jennings
Format:	Article
Language:	English
Published:	Elsevier 2021-01-01
Series:	Results in Chemistry
Subjects:	Allylsilane Dihydroxylation Natural products Olefination Diastereoselective synthesis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211715621001557

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