| Summary: | Background: Glioblastoma (GBM) is a rapidly growing malignant brain tumor that varies in shape and size and causes various clinical symptoms. A case of a right temporal lobe GBM with a very rare presentation as an acute ischemic stroke due to anterior choroidal artery (AchoA) occlusion is presented along with a review of the literature. Case description: A 74-year-old woman presented with acute onset of severe left hemiparesis. Imaging showed an acute ischemic lesion in the territory of the right AchoA and a right temporal lobe tumor. Tumor resection with anterior temporal lobectomy was performed. The operative findings showed that the AchoA was encased in the tumor. The pathological examination and the genetic analysis led to the diagnosis of GBM. Conclusions: Though it is very rare, GBM can cause acute ischemic stroke by mechanical compression, arterial dissection, or tumor infiltration to the vascular wall.
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