Toxic Epidermal Necrolysis: The Experience of Coimbra’s Burn Unit
Introduction: Toxic Epidermal Necrolysis is a drug-induced life-threatening systemic disease, characterized by extensive dermoepidermal detachment and mucositis. At least 95% of cases are believed to be drug-induced. SCORTEN is a scoring system used to stratify severity and predict mortality. Treatm...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ordem dos Médicos
2013-08-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/150 |
| _version_ | 1797996323036725248 |
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| author | Susana Pinheiro Ricardo Carvalho Sara Ramos Carla Diogo Marisa Caetano Luís Cabral Celso Cruzeiro |
| author_facet | Susana Pinheiro Ricardo Carvalho Sara Ramos Carla Diogo Marisa Caetano Luís Cabral Celso Cruzeiro |
| author_sort | Susana Pinheiro |
| collection | DOAJ |
| description | Introduction: Toxic Epidermal Necrolysis is a drug-induced life-threatening systemic disease, characterized by extensive dermoepidermal detachment and mucositis. At least 95% of cases are believed to be drug-induced. SCORTEN is a scoring system used to stratify severity and predict mortality. Treatment demands immediate withdrawal of the causative drug and early transfer to a burn centre for specific and intensive care.
Material and Methods: Authors have performed a retrospective study of 21 consecutive patients with SJS/ Toxic Epidermal Necrolysis admitted in the Burn Centre of Coimbra’s University Hospital, between January 1999 and December 2010, and have compared the actual mortality rate with that predicted by SCORTEN, in order to assess the predictive capacity of SCORTEN. Analysis of results and
treatment options were conducted. Data were analysed in SPSS 17.0®.
Results: Thirteen females (61.9%) and 8 males (38.1%) were treated, mean age 55.6 ± 23.7 years and with a mean of 51% ± 22.4% epidermal detachment. The overall observed mortality rate was 47.6% and the one predicted by SCORTEN 42.2%. Immediate withdrawal of the causative drug and early transfer of the patient to our burn centre were the basis of treatment.
Conclusion: Toxic Epidermal Necrolysis pathophysiology remains to be clarified and no specific treatment has unequivocally proven to be effective. SCORTEN seems to be an accurate scoring system for estimation of mortality rate. |
| first_indexed | 2024-04-11T10:15:41Z |
| format | Article |
| id | doaj.art-f35acf0d2ddc48a88c28f8bcb8f1ee37 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-11T10:15:41Z |
| publishDate | 2013-08-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-f35acf0d2ddc48a88c28f8bcb8f1ee372022-12-22T04:29:59ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582013-08-0126410.20344/amp.150Toxic Epidermal Necrolysis: The Experience of Coimbra’s Burn UnitSusana Pinheiro0Ricardo Carvalho1Sara Ramos2Carla Diogo3Marisa Caetano4Luís Cabral5Celso Cruzeiro6Serviço de Cirurgia Plástica e Queimados. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Serviço de Cirurgia Plástica e Queimados. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Serviço de Cirurgia Plástica e Queimados. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Serviço de Cirurgia Plástica e Queimados. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Serviços Farmacêuticos. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Serviço de Cirurgia Plástica e Queimados. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Serviço de Cirurgia Plástica e Queimados. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Introduction: Toxic Epidermal Necrolysis is a drug-induced life-threatening systemic disease, characterized by extensive dermoepidermal detachment and mucositis. At least 95% of cases are believed to be drug-induced. SCORTEN is a scoring system used to stratify severity and predict mortality. Treatment demands immediate withdrawal of the causative drug and early transfer to a burn centre for specific and intensive care. Material and Methods: Authors have performed a retrospective study of 21 consecutive patients with SJS/ Toxic Epidermal Necrolysis admitted in the Burn Centre of Coimbra’s University Hospital, between January 1999 and December 2010, and have compared the actual mortality rate with that predicted by SCORTEN, in order to assess the predictive capacity of SCORTEN. Analysis of results and treatment options were conducted. Data were analysed in SPSS 17.0®. Results: Thirteen females (61.9%) and 8 males (38.1%) were treated, mean age 55.6 ± 23.7 years and with a mean of 51% ± 22.4% epidermal detachment. The overall observed mortality rate was 47.6% and the one predicted by SCORTEN 42.2%. Immediate withdrawal of the causative drug and early transfer of the patient to our burn centre were the basis of treatment. Conclusion: Toxic Epidermal Necrolysis pathophysiology remains to be clarified and no specific treatment has unequivocally proven to be effective. SCORTEN seems to be an accurate scoring system for estimation of mortality rate. https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/150 |
| spellingShingle | Susana Pinheiro Ricardo Carvalho Sara Ramos Carla Diogo Marisa Caetano Luís Cabral Celso Cruzeiro Toxic Epidermal Necrolysis: The Experience of Coimbra’s Burn Unit Acta Médica Portuguesa |
| title | Toxic Epidermal Necrolysis: The Experience of Coimbra’s Burn Unit |
| title_full | Toxic Epidermal Necrolysis: The Experience of Coimbra’s Burn Unit |
| title_fullStr | Toxic Epidermal Necrolysis: The Experience of Coimbra’s Burn Unit |
| title_full_unstemmed | Toxic Epidermal Necrolysis: The Experience of Coimbra’s Burn Unit |
| title_short | Toxic Epidermal Necrolysis: The Experience of Coimbra’s Burn Unit |
| title_sort | toxic epidermal necrolysis the experience of coimbra s burn unit |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/150 |
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