How Gut Microbes Nurture Intestinal Stem Cells: A <i>Drosophila</i> Perspective
Host-microbiota interactions are key modulators of host physiology and behavior. Accumulating evidence suggests that the complex interplay between microbiota, diet and the intestine controls host health. Great emphasis has been given on how gut microbes have evolved to harvest energy from the diet t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-02-01
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| Series: | Metabolites |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-1989/12/2/169 |
| _version_ | 1797478092251332608 |
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| author | Constantina Neophytou Chrysoula Pitsouli |
| author_facet | Constantina Neophytou Chrysoula Pitsouli |
| author_sort | Constantina Neophytou |
| collection | DOAJ |
| description | Host-microbiota interactions are key modulators of host physiology and behavior. Accumulating evidence suggests that the complex interplay between microbiota, diet and the intestine controls host health. Great emphasis has been given on how gut microbes have evolved to harvest energy from the diet to control energy balance, host metabolism and fitness. In addition, many metabolites essential for intestinal homeostasis are mainly derived from gut microbiota and can alleviate nutritional imbalances. However, due to the high complexity of the system, the molecular mechanisms that control host-microbiota mutualism, as well as whether and how microbiota affects host intestinal stem cells (ISCs) remain elusive. <i>Drosophila</i> encompasses a low complexity intestinal microbiome and has recently emerged as a system that might uncover evolutionarily conserved mechanisms of microbiota-derived nutrient ISC regulation. Here, we review recent studies using the <i>Drosophila</i> model that directly link microbiota-derived metabolites and ISC function. This research field provides exciting perspectives for putative future treatments of ISC-related diseases based on monitoring and manipulating intestinal microbiota. |
| first_indexed | 2024-03-09T21:28:06Z |
| format | Article |
| id | doaj.art-f35cf14def8e41e8888beddfe3d9e181 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T21:28:06Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-f35cf14def8e41e8888beddfe3d9e1812023-11-23T21:05:29ZengMDPI AGMetabolites2218-19892022-02-0112216910.3390/metabo12020169How Gut Microbes Nurture Intestinal Stem Cells: A <i>Drosophila</i> PerspectiveConstantina Neophytou0Chrysoula Pitsouli1Department of Biological Sciences, University of Cyprus, 1 University Avenue, Aglantzia, Nicosia 2109, CyprusDepartment of Biological Sciences, University of Cyprus, 1 University Avenue, Aglantzia, Nicosia 2109, CyprusHost-microbiota interactions are key modulators of host physiology and behavior. Accumulating evidence suggests that the complex interplay between microbiota, diet and the intestine controls host health. Great emphasis has been given on how gut microbes have evolved to harvest energy from the diet to control energy balance, host metabolism and fitness. In addition, many metabolites essential for intestinal homeostasis are mainly derived from gut microbiota and can alleviate nutritional imbalances. However, due to the high complexity of the system, the molecular mechanisms that control host-microbiota mutualism, as well as whether and how microbiota affects host intestinal stem cells (ISCs) remain elusive. <i>Drosophila</i> encompasses a low complexity intestinal microbiome and has recently emerged as a system that might uncover evolutionarily conserved mechanisms of microbiota-derived nutrient ISC regulation. Here, we review recent studies using the <i>Drosophila</i> model that directly link microbiota-derived metabolites and ISC function. This research field provides exciting perspectives for putative future treatments of ISC-related diseases based on monitoring and manipulating intestinal microbiota.https://www.mdpi.com/2218-1989/12/2/169intestinal stem cellsmidgutmicrobiotanutrientsvitaminsfatty acids |
| spellingShingle | Constantina Neophytou Chrysoula Pitsouli How Gut Microbes Nurture Intestinal Stem Cells: A <i>Drosophila</i> Perspective Metabolites intestinal stem cells midgut microbiota nutrients vitamins fatty acids |
| title | How Gut Microbes Nurture Intestinal Stem Cells: A <i>Drosophila</i> Perspective |
| title_full | How Gut Microbes Nurture Intestinal Stem Cells: A <i>Drosophila</i> Perspective |
| title_fullStr | How Gut Microbes Nurture Intestinal Stem Cells: A <i>Drosophila</i> Perspective |
| title_full_unstemmed | How Gut Microbes Nurture Intestinal Stem Cells: A <i>Drosophila</i> Perspective |
| title_short | How Gut Microbes Nurture Intestinal Stem Cells: A <i>Drosophila</i> Perspective |
| title_sort | how gut microbes nurture intestinal stem cells a i drosophila i perspective |
| topic | intestinal stem cells midgut microbiota nutrients vitamins fatty acids |
| url | https://www.mdpi.com/2218-1989/12/2/169 |
| work_keys_str_mv | AT constantinaneophytou howgutmicrobesnurtureintestinalstemcellsaidrosophilaiperspective AT chrysoulapitsouli howgutmicrobesnurtureintestinalstemcellsaidrosophilaiperspective |