Analysis of Clinical Characteristics, Background, and Paroxysmal Activity in EEG of Patients with Juvenile Myoclonic Epilepsy
Juvenile myoclonic epilepsy (JME) appears in adolescence with myoclonic, absence, and generalized tonic clonic (GTC) seizures with paroxysmal activity of polyspike and slow wave (PSW), or spike and wave (SW) complexes in EEG. Our aim was to analyze the clinical characteristics, background EEG activi...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/12/1/29 |
| _version_ | 1797495436780503040 |
|---|---|
| author | Efraín Santiago-Rodríguez Elba Zaldívar-Uribe |
| author_facet | Efraín Santiago-Rodríguez Elba Zaldívar-Uribe |
| author_sort | Efraín Santiago-Rodríguez |
| collection | DOAJ |
| description | Juvenile myoclonic epilepsy (JME) appears in adolescence with myoclonic, absence, and generalized tonic clonic (GTC) seizures with paroxysmal activity of polyspike and slow wave (PSW), or spike and wave (SW) complexes in EEG. Our aim was to analyze the clinical characteristics, background EEG activity, and paroxysmal events in 41 patients with JME. Background EEG activity was analyzed with visual, quantitative (QEEG), and neurometric parameters. Our JME patients started with absence seizures at 11.4 ± 1.5 years old, myoclonic seizures at 13.6 ± 2.5 years, and GTC seizures at 15.1 ± 0.8 years. The seizures presented in awakening at 7:39 h with sleep deprivation, alcoholic beverage intake, and stress as the most frequent precipitant factors. Paroxysmal activity was of PSW and fast SW complexes with 40.5 ± 62.6 events/hour and a duration of 1.7 s. Right asymmetric paroxysmal activity was present in 68.3% of patients. Background EEG activity was abnormal in 31.7% of patients with visual analysis. With QEEG beta AP (absolute power) increase and AP delta decrease were the most frequent abnormalities found. Spectral analysis showed that 48.7% of patients had normal results, and 26.83% and 24.4% had higher and lower frequencies than 10.156 Hz, respectively. We concluded that, with visual analysis, background EEG activity was abnormal in a few patients and the abnormalities increased when QEEG was used. |
| first_indexed | 2024-03-10T01:49:36Z |
| format | Article |
| id | doaj.art-f35d8a3b85b3497dbee3ce1a022ad424 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T01:49:36Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-f35d8a3b85b3497dbee3ce1a022ad4242023-11-23T13:08:59ZengMDPI AGBrain Sciences2076-34252021-12-011212910.3390/brainsci12010029Analysis of Clinical Characteristics, Background, and Paroxysmal Activity in EEG of Patients with Juvenile Myoclonic EpilepsyEfraín Santiago-Rodríguez0Elba Zaldívar-Uribe1Diagnóstico, Tratamiento e Investigación Neurológica, S. C. Querétaro, Santiago de Queretaro 76177, MexicoDiagnóstico, Tratamiento e Investigación Neurológica, S. C. Querétaro, Santiago de Queretaro 76177, MexicoJuvenile myoclonic epilepsy (JME) appears in adolescence with myoclonic, absence, and generalized tonic clonic (GTC) seizures with paroxysmal activity of polyspike and slow wave (PSW), or spike and wave (SW) complexes in EEG. Our aim was to analyze the clinical characteristics, background EEG activity, and paroxysmal events in 41 patients with JME. Background EEG activity was analyzed with visual, quantitative (QEEG), and neurometric parameters. Our JME patients started with absence seizures at 11.4 ± 1.5 years old, myoclonic seizures at 13.6 ± 2.5 years, and GTC seizures at 15.1 ± 0.8 years. The seizures presented in awakening at 7:39 h with sleep deprivation, alcoholic beverage intake, and stress as the most frequent precipitant factors. Paroxysmal activity was of PSW and fast SW complexes with 40.5 ± 62.6 events/hour and a duration of 1.7 s. Right asymmetric paroxysmal activity was present in 68.3% of patients. Background EEG activity was abnormal in 31.7% of patients with visual analysis. With QEEG beta AP (absolute power) increase and AP delta decrease were the most frequent abnormalities found. Spectral analysis showed that 48.7% of patients had normal results, and 26.83% and 24.4% had higher and lower frequencies than 10.156 Hz, respectively. We concluded that, with visual analysis, background EEG activity was abnormal in a few patients and the abnormalities increased when QEEG was used.https://www.mdpi.com/2076-3425/12/1/29juvenile myoclonic epilepsyparoxysmal activityelectroencephalogramquantitative EEG analysispolyspike and wave complexes |
| spellingShingle | Efraín Santiago-Rodríguez Elba Zaldívar-Uribe Analysis of Clinical Characteristics, Background, and Paroxysmal Activity in EEG of Patients with Juvenile Myoclonic Epilepsy Brain Sciences juvenile myoclonic epilepsy paroxysmal activity electroencephalogram quantitative EEG analysis polyspike and wave complexes |
| title | Analysis of Clinical Characteristics, Background, and Paroxysmal Activity in EEG of Patients with Juvenile Myoclonic Epilepsy |
| title_full | Analysis of Clinical Characteristics, Background, and Paroxysmal Activity in EEG of Patients with Juvenile Myoclonic Epilepsy |
| title_fullStr | Analysis of Clinical Characteristics, Background, and Paroxysmal Activity in EEG of Patients with Juvenile Myoclonic Epilepsy |
| title_full_unstemmed | Analysis of Clinical Characteristics, Background, and Paroxysmal Activity in EEG of Patients with Juvenile Myoclonic Epilepsy |
| title_short | Analysis of Clinical Characteristics, Background, and Paroxysmal Activity in EEG of Patients with Juvenile Myoclonic Epilepsy |
| title_sort | analysis of clinical characteristics background and paroxysmal activity in eeg of patients with juvenile myoclonic epilepsy |
| topic | juvenile myoclonic epilepsy paroxysmal activity electroencephalogram quantitative EEG analysis polyspike and wave complexes |
| url | https://www.mdpi.com/2076-3425/12/1/29 |
| work_keys_str_mv | AT efrainsantiagorodriguez analysisofclinicalcharacteristicsbackgroundandparoxysmalactivityineegofpatientswithjuvenilemyoclonicepilepsy AT elbazaldivaruribe analysisofclinicalcharacteristicsbackgroundandparoxysmalactivityineegofpatientswithjuvenilemyoclonicepilepsy |