Irisin Contributes to Neuroprotection by Promoting Mitochondrial Biogenesis After Experimental Subarachnoid Hemorrhage

Irisin Contributes to Neuroprotection by Promoting Mitochondrial Biogenesis After Experimental Subarachnoid Hemorrhage

Subarachnoid hemorrhage (SAH) is a devastating form of stroke, which poses a series of intractable challenges to clinical practice. Imbalance of mitochondrial homeostasis has been thought to be the crucial pathomechanism in early brain injury (EBI) cascade after SAH. Irisin, a protein related to met...

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Bibliographic Details
Main Authors: Tianqi Tu, Shigang Yin, Jinwei Pang, Xianhui Zhang, Lifang Zhang, Yuxuan Zhang, Yuke Xie, Kecheng Guo, Ligang Chen, Jianhua Peng, Yong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
FNDC5/irisin
subarachnoid hemorrhage
mitochondrial homeostasis
oxidative stress
neuronal apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.640215/full

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