Maternal catalase supplementation regulates fatty acid metabolism and antioxidant ability of lactating sows and their offspring
Introduction and methodsAs a crucial antioxidant enzyme, catalase (CAT) could destroy the cellular hydrogen peroxide to mitigate oxidative stress. The current study aimed to investigate the effects of maternal CAT supplementation from late gestation to day 14 of lactation on antioxidant ability and...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.1014313/full |
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| author | Tiantian Zhou Bei Cheng Lumin Gao Fengyun Ren Fengyun Ren Guanglun Guo Teketay Wassie Xin Wu Xin Wu Xin Wu |
| author_facet | Tiantian Zhou Bei Cheng Lumin Gao Fengyun Ren Fengyun Ren Guanglun Guo Teketay Wassie Xin Wu Xin Wu Xin Wu |
| author_sort | Tiantian Zhou |
| collection | DOAJ |
| description | Introduction and methodsAs a crucial antioxidant enzyme, catalase (CAT) could destroy the cellular hydrogen peroxide to mitigate oxidative stress. The current study aimed to investigate the effects of maternal CAT supplementation from late gestation to day 14 of lactation on antioxidant ability and fatty acids metabolism with regard to the sow-piglet-axis. On day 95 of gestation, forty sows were divided into control (CON) group (fed a basal diet) and CAT group (fed a basal diet supplemented with 660 mg/kg CAT), the feeding experiment ended on day 14 of lactation.ResultsThe lactating sows in the CAT group produced more milk, and had higher antioxidant enzymes activity including POD and GSH-Px (P < 0.05), lower content of serum LDL as well as plasmic C18:3n3 content (P < 0.05). Additionally, maternal CAT supplementation improved offspring's body weight at day 14 of nursing period and ADG (P < 0.05), and regulated the antioxidant ability as evidenced by decreased related enzymes activity such as T-AOC and CAT and changed genes expression level. It significantly affected lipid metabolism of suckling piglets manifested by increasing the serum ALT, CHOL, and LDL (P < 0.05) level and modulating plasma medium- and long-chain fatty acids (MCFAs and LCFAs), as well as regulating the genes expression involved in lipid metabolism.ConclusionMaternal CAT supplementation could regulate the fatty acid composition and enhance the antioxidant ability of sows and offspring during the lactating period and further promote the growth of suckling piglets. These findings might provide a reference value for the utilization of CAT as supplement for mother from late pregnancy to lactation period to promote the fatty acid metabolism of offspring. |
| first_indexed | 2024-04-11T15:02:16Z |
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| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-11T15:02:16Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-f3603f836a994fef9e538dbc35c52f192022-12-22T04:16:55ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-11-01910.3389/fvets.2022.10143131014313Maternal catalase supplementation regulates fatty acid metabolism and antioxidant ability of lactating sows and their offspringTiantian Zhou0Bei Cheng1Lumin Gao2Fengyun Ren3Fengyun Ren4Guanglun Guo5Teketay Wassie6Xin Wu7Xin Wu8Xin Wu9CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, ChinaHunan Co-Innovation Center of Safety Animal Production, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaHunan Co-Innovation Center of Safety Animal Production, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, ChinaHunan Co-Innovation Center of Safety Animal Production, College of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, ChinaIntroduction and methodsAs a crucial antioxidant enzyme, catalase (CAT) could destroy the cellular hydrogen peroxide to mitigate oxidative stress. The current study aimed to investigate the effects of maternal CAT supplementation from late gestation to day 14 of lactation on antioxidant ability and fatty acids metabolism with regard to the sow-piglet-axis. On day 95 of gestation, forty sows were divided into control (CON) group (fed a basal diet) and CAT group (fed a basal diet supplemented with 660 mg/kg CAT), the feeding experiment ended on day 14 of lactation.ResultsThe lactating sows in the CAT group produced more milk, and had higher antioxidant enzymes activity including POD and GSH-Px (P < 0.05), lower content of serum LDL as well as plasmic C18:3n3 content (P < 0.05). Additionally, maternal CAT supplementation improved offspring's body weight at day 14 of nursing period and ADG (P < 0.05), and regulated the antioxidant ability as evidenced by decreased related enzymes activity such as T-AOC and CAT and changed genes expression level. It significantly affected lipid metabolism of suckling piglets manifested by increasing the serum ALT, CHOL, and LDL (P < 0.05) level and modulating plasma medium- and long-chain fatty acids (MCFAs and LCFAs), as well as regulating the genes expression involved in lipid metabolism.ConclusionMaternal CAT supplementation could regulate the fatty acid composition and enhance the antioxidant ability of sows and offspring during the lactating period and further promote the growth of suckling piglets. These findings might provide a reference value for the utilization of CAT as supplement for mother from late pregnancy to lactation period to promote the fatty acid metabolism of offspring.https://www.frontiersin.org/articles/10.3389/fvets.2022.1014313/fullcatalaseantioxidantfatty acidlipid metabolismsuckling pigletsows |
| spellingShingle | Tiantian Zhou Bei Cheng Lumin Gao Fengyun Ren Fengyun Ren Guanglun Guo Teketay Wassie Xin Wu Xin Wu Xin Wu Maternal catalase supplementation regulates fatty acid metabolism and antioxidant ability of lactating sows and their offspring Frontiers in Veterinary Science catalase antioxidant fatty acid lipid metabolism suckling piglet sows |
| title | Maternal catalase supplementation regulates fatty acid metabolism and antioxidant ability of lactating sows and their offspring |
| title_full | Maternal catalase supplementation regulates fatty acid metabolism and antioxidant ability of lactating sows and their offspring |
| title_fullStr | Maternal catalase supplementation regulates fatty acid metabolism and antioxidant ability of lactating sows and their offspring |
| title_full_unstemmed | Maternal catalase supplementation regulates fatty acid metabolism and antioxidant ability of lactating sows and their offspring |
| title_short | Maternal catalase supplementation regulates fatty acid metabolism and antioxidant ability of lactating sows and their offspring |
| title_sort | maternal catalase supplementation regulates fatty acid metabolism and antioxidant ability of lactating sows and their offspring |
| topic | catalase antioxidant fatty acid lipid metabolism suckling piglet sows |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.1014313/full |
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