Evaluation of salivary opiorphin levels in patients with atypical facial pain
Background and Aims: Atypical facial pain (AFP) is a chronic disease associated with local pain in the craniofacial area. A wide range of treatments including drug therapy, psychiatric methods and open surgery are used for its treatment. Opiorphin is a pentapeptide that can block pain and also has p...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2022-05-01
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| Series: | Journal of Dental Medicine |
| Subjects: | |
| Online Access: | http://jdm.tums.ac.ir/article-1-6147-en.pdf |
| _version_ | 1797800473290342400 |
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| author | Zohreh Dalirsani Maryam Amirchaghmaghi Mahshid Malakouti Semnani Mahdi Talebi Seyed Isaac Hashemi Mohammad Taghi Shakeri |
| author_facet | Zohreh Dalirsani Maryam Amirchaghmaghi Mahshid Malakouti Semnani Mahdi Talebi Seyed Isaac Hashemi Mohammad Taghi Shakeri |
| author_sort | Zohreh Dalirsani |
| collection | DOAJ |
| description | Background and Aims: Atypical facial pain (AFP) is a chronic disease associated with local pain in the craniofacial area. A wide range of treatments including drug therapy, psychiatric methods and open surgery are used for its treatment. Opiorphin is a pentapeptide that can block pain and also has proven antidepressant effects. The aim of this study was conducted to investigate the opiorphin concentration in AFP patients and to compare it with healthy people.
Materials and Methods: This study was performed on 30 AFP patients and 40 healthy individuals. Unstimulated saliva was collected from both groups by spitting method. HAD-A (Hamilton Anxiety Test) and HAD-D (Hamilton Depression Test) questionnaires were completed for all patients and controls. Psychological interview with the patients and psychological analysis were performed to determine anxiety and depression scores. Data analysis was done using SPSS (ver.24) statistical software
Results: The subjects of two groups were homogeneous in terms of age and sex. The mean salivary opiorphin concentrations in the case and control groups were 1.8050±0.2923 and 1.8032±0.3682 ng/ml, respectively. According to the results of t-Test, no significant difference was observed in the mean opiorphin concentration between the AFP group and control group (P=1.000). According to the Pearson's test, no significant relationship was found between the opiorphin levels and the age, sex, and anxiety or depression score in the patient and control groups (P>0.05). Also, there was no remarkable correlation between initial VAS, duration of pain and previous treatments with opiorphin levels in the AFP patients (P>0.05). No significant correlation was found between the opiorphin concentration and menopausal period in the case and control women (P>0.05).
Conclusion: The results showed that most AFP patients had some degree of anxiety and depression. However, salivary opiorphin concentration did not significantly increase in the AFP patients. |
| first_indexed | 2024-03-13T04:35:49Z |
| format | Article |
| id | doaj.art-f361b075eb8f4df5a4c7386e3de1aa12 |
| institution | Directory Open Access Journal |
| issn | 1024-641X 2008-2444 |
| language | fas |
| last_indexed | 2024-03-13T04:35:49Z |
| publishDate | 2022-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Journal of Dental Medicine |
| spelling | doaj.art-f361b075eb8f4df5a4c7386e3de1aa122023-06-19T06:57:17ZfasTehran University of Medical SciencesJournal of Dental Medicine1024-641X2008-24442022-05-013518Evaluation of salivary opiorphin levels in patients with atypical facial painZohreh Dalirsani0Maryam Amirchaghmaghi1Mahshid Malakouti Semnani2Mahdi Talebi3Seyed Isaac Hashemi4Mohammad Taghi Shakeri5 Member of Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Member of Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Post-Graduate Student, Department of Oral and Maxillofacial Diseases, School of Dentistry, Mashhad University of Sciences, Mashhad, Iran Assistant Professor of Psychiatry, Department of Community and Family Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Member of Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Member of Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Background and Aims: Atypical facial pain (AFP) is a chronic disease associated with local pain in the craniofacial area. A wide range of treatments including drug therapy, psychiatric methods and open surgery are used for its treatment. Opiorphin is a pentapeptide that can block pain and also has proven antidepressant effects. The aim of this study was conducted to investigate the opiorphin concentration in AFP patients and to compare it with healthy people. Materials and Methods: This study was performed on 30 AFP patients and 40 healthy individuals. Unstimulated saliva was collected from both groups by spitting method. HAD-A (Hamilton Anxiety Test) and HAD-D (Hamilton Depression Test) questionnaires were completed for all patients and controls. Psychological interview with the patients and psychological analysis were performed to determine anxiety and depression scores. Data analysis was done using SPSS (ver.24) statistical software Results: The subjects of two groups were homogeneous in terms of age and sex. The mean salivary opiorphin concentrations in the case and control groups were 1.8050±0.2923 and 1.8032±0.3682 ng/ml, respectively. According to the results of t-Test, no significant difference was observed in the mean opiorphin concentration between the AFP group and control group (P=1.000). According to the Pearson's test, no significant relationship was found between the opiorphin levels and the age, sex, and anxiety or depression score in the patient and control groups (P>0.05). Also, there was no remarkable correlation between initial VAS, duration of pain and previous treatments with opiorphin levels in the AFP patients (P>0.05). No significant correlation was found between the opiorphin concentration and menopausal period in the case and control women (P>0.05). Conclusion: The results showed that most AFP patients had some degree of anxiety and depression. However, salivary opiorphin concentration did not significantly increase in the AFP patients.http://jdm.tums.ac.ir/article-1-6147-en.pdfopiorphinfacial paindepressionanxiety |
| spellingShingle | Zohreh Dalirsani Maryam Amirchaghmaghi Mahshid Malakouti Semnani Mahdi Talebi Seyed Isaac Hashemi Mohammad Taghi Shakeri Evaluation of salivary opiorphin levels in patients with atypical facial pain Journal of Dental Medicine opiorphin facial pain depression anxiety |
| title | Evaluation of salivary opiorphin levels in patients with atypical facial pain |
| title_full | Evaluation of salivary opiorphin levels in patients with atypical facial pain |
| title_fullStr | Evaluation of salivary opiorphin levels in patients with atypical facial pain |
| title_full_unstemmed | Evaluation of salivary opiorphin levels in patients with atypical facial pain |
| title_short | Evaluation of salivary opiorphin levels in patients with atypical facial pain |
| title_sort | evaluation of salivary opiorphin levels in patients with atypical facial pain |
| topic | opiorphin facial pain depression anxiety |
| url | http://jdm.tums.ac.ir/article-1-6147-en.pdf |
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